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Theranostics 2022; 12(15):6446-6454. doi:10.7150/thno.78016 This issue Cite

Review

Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair

Yangdan Liu*, Chiakang Ho*, Dongsheng Wen*, Jiaming Sun, Lu Huang, Ya Gao✉, Qingfeng Li✉, Yifan Zhang✉

Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
* Yangdan Liu, Chiakang Ho and Dongsheng Wen contributed equally to this work.

✉ Corresponding authors: Yifan Zhang, Qingfeng Li and Ya Gao. Address: 639 Zhizaoju Road, Depart of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. Tel: More

Citation:
Liu Y, Ho C, Wen D, Sun J, Huang L, Gao Y, Li Q, Zhang Y. Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair. Theranostics 2022; 12(15):6446-6454. doi:10.7150/thno.78016. https://www.thno.org/v12p6446.htm
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Abstract

Graphic abstract

The skin epidermis and appendages undergo ongoing renewal throughout life. Stem cells residing in the epidermis and hair follicles are pivotal for sustaining skin homeostasis. The self-renewal ability of stem cells significantly decreases during skin aging but actively increases during wound repair. Residential stem cells reside in niches that provide spatially distinct microenvironments for stem cell maintenance and function. Cell-extracellular matrix (ECM) adhesion is essential for the establishment of niche architecture. Collagen XVII (COL17), as a transmembrane protein constituting hemidesmosomes (HDs), mediates the interactions of stem cells with surrounding cells and the matrix to regulate skin homeostasis, aging and wound repair. This review focuses on the pivotal role of the niche component COL17 in stem cell maintenance and its function in regulation of skin aging and wound repair.

Keywords: Collagen XVII, Aging, Wound repair, Stem cell, Stem cell niche

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APA
Liu, Y., Ho, C., Wen, D., Sun, J., Huang, L., Gao, Y., Li, Q., Zhang, Y. (2022). Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair. Theranostics, 12(15), 6446-6454. https://doi.org/10.7150/thno.78016.

ACS
Liu, Y.; Ho, C.; Wen, D.; Sun, J.; Huang, L.; Gao, Y.; Li, Q.; Zhang, Y. Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair. Theranostics 2022, 12 (15), 6446-6454. DOI: 10.7150/thno.78016.

NLM
Liu Y, Ho C, Wen D, Sun J, Huang L, Gao Y, Li Q, Zhang Y. Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair. Theranostics 2022; 12(15):6446-6454. doi:10.7150/thno.78016. https://www.thno.org/v12p6446.htm

CSE
Liu Y, Ho C, Wen D, Sun J, Huang L, Gao Y, Li Q, Zhang Y. 2022. Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair. Theranostics. 12(15):6446-6454.

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