Recent advances in understanding the role of HES6 in cancers

Krossa, Imène; Strub, Thomas; Martel, Arnaud; Nahon-Esteve, Sacha; Lassalle, Sandra; Hofman, Paul; Baillif, Stéphanie; Ballotti, Robert; Bertolotto, Corine

doi:10.7150/thno.72966

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Theranostics 2022; 12(9):4374-4385. doi:10.7150/thno.72966 This issue Cite

Review

Recent advances in understanding the role of HES6 in cancers

Imène Krossa^1,2,‡, Thomas Strub^1,2,‡, Arnaud Martel^1,3,‡, Sacha Nahon-Esteve^1,3, Sandra Lassalle^1,4, Paul Hofman^1,4, Stéphanie Baillif^1,3, Robert Ballotti^1,2,#, Corine Bertolotto^1,2,✉

1. Université Côte d'Azur, France
2. Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France
3. Centre Hospitalier Universitaire de Nice, Department of Ophthalmology, Nice, France
4. Laboratoire de Pathologie clinique et expérimentale, biobanque BB-0033-00025, and IRCAN team 4, FHU OncoAge, Nice, France
‡: These authors equally contributed
#: These authors jointly supervised this work

Citation:

Krossa I, Strub T, Martel A, Nahon-Esteve S, Lassalle S, Hofman P, Baillif S, Ballotti R, Bertolotto C. Recent advances in understanding the role of HES6 in cancers. Theranostics 2022; 12(9):4374-4385. doi:10.7150/thno.72966. https://www.thno.org/v12p4374.htm

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Abstract

The NOTCH signaling system regulates a variety of cellular processes during embryonic development and homeostasis maintenance in different tissues and contexts. Hence, dysregulation of NOTCH signaling is associated with a plethora of human cancers, and there have been multiple efforts to target key components of this pathway. In this review, we briefly highlight the latest research advances in understanding HES6, a poorly studied component of the NOTCH pathway. We summarize the role of HES6 in cancers with a focus on uveal melanoma. Finally, we discuss the ongoing efforts to target the NOTCH-HES6 axis in cancers.

Keywords: HES6, cancers, uveal melanoma, NOTCH, signaling

Citation styles

APA

Krossa, I., Strub, T., Martel, A., Nahon-Esteve, S., Lassalle, S., Hofman, P., Baillif, S., Ballotti, R., Bertolotto, C. (2022). Recent advances in understanding the role of HES6 in cancers. Theranostics, 12(9), 4374-4385. https://doi.org/10.7150/thno.72966.

ACS

Krossa, I.; Strub, T.; Martel, A.; Nahon-Esteve, S.; Lassalle, S.; Hofman, P.; Baillif, S.; Ballotti, R.; Bertolotto, C. Recent advances in understanding the role of HES6 in cancers. Theranostics 2022, 12 (9), 4374-4385. DOI: 10.7150/thno.72966.

NLM

CSE

Krossa I, Strub T, Martel A, Nahon-Esteve S, Lassalle S, Hofman P, Baillif S, Ballotti R, Bertolotto C. 2022. Recent advances in understanding the role of HES6 in cancers. Theranostics. 12(9):4374-4385.

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