Theranostics 2021; 11(15):7199-7221. doi:10.7150/thno.57745 This issue Cite

Review

Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives

Jie Gao1,2,3, Yifeng Zhang1,2, Xihong Liu4, Xiayi Wu1, Luqi Huang3✉, Wei Gao2,1,5✉

1. School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China.
2. Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
3. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, Chinese Academy of Chinese Medical Sciences, Beijing, 100700, China.
4. Basic Medical College, Henan University of Chinese Medicine, Zhengzhou 450046, China.
5. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, China.

Citation:
Gao J, Zhang Y, Liu X, Wu X, Huang L, Gao W. Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives. Theranostics 2021; 11(15):7199-7221. doi:10.7150/thno.57745. https://www.thno.org/v11p7199.htm
Other styles

File import instruction

Abstract

Graphic abstract

Triptolide, an abietane-type diterpenoid isolated from Tripterygium wilfordii Hook. F., has significant pharmacological activity. Research results show that triptolide has obvious inhibitory effects on many solid tumors. Therefore, triptolide has become one of the lead compounds candidates for being the next "blockbuster" drug, and multiple triptolide derivatives have entered clinical research. An increasing number of researchers have developed triptolide synthesis methods to meet the clinical need. To provide new ideas for researchers in different disciplines and connect different disciplines with researchers aiming to solve scientific problems more efficiently, this article reviews the research progress made with analyzes of triptolide pharmacological activity, biosynthetic pathways, and chemical synthesis pathways and reported in toxicological and clinical studies of derivatives over the past 20 years, which have laid the foundation for subsequent researchers to study triptolide in many ways.

Keywords: Tripterygium wilfordii, Triptolide, Biological activities, Biosynthesis, Chemical synthesis


Citation styles

APA
Gao, J., Zhang, Y., Liu, X., Wu, X., Huang, L., Gao, W. (2021). Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives. Theranostics, 11(15), 7199-7221. https://doi.org/10.7150/thno.57745.

ACS
Gao, J.; Zhang, Y.; Liu, X.; Wu, X.; Huang, L.; Gao, W. Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives. Theranostics 2021, 11 (15), 7199-7221. DOI: 10.7150/thno.57745.

NLM
Gao J, Zhang Y, Liu X, Wu X, Huang L, Gao W. Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives. Theranostics 2021; 11(15):7199-7221. doi:10.7150/thno.57745. https://www.thno.org/v11p7199.htm

CSE
Gao J, Zhang Y, Liu X, Wu X, Huang L, Gao W. 2021. Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives. Theranostics. 11(15):7199-7221.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image