Theranostics 2021; 11(15):7199-7221. doi:10.7150/thno.57745 This issue Cite
Review
1. School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China.
2. Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
3. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, Chinese Academy of Chinese Medical Sciences, Beijing, 100700, China.
4. Basic Medical College, Henan University of Chinese Medicine, Zhengzhou 450046, China.
5. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, China.
Triptolide, an abietane-type diterpenoid isolated from Tripterygium wilfordii Hook. F., has significant pharmacological activity. Research results show that triptolide has obvious inhibitory effects on many solid tumors. Therefore, triptolide has become one of the lead compounds candidates for being the next "blockbuster" drug, and multiple triptolide derivatives have entered clinical research. An increasing number of researchers have developed triptolide synthesis methods to meet the clinical need. To provide new ideas for researchers in different disciplines and connect different disciplines with researchers aiming to solve scientific problems more efficiently, this article reviews the research progress made with analyzes of triptolide pharmacological activity, biosynthetic pathways, and chemical synthesis pathways and reported in toxicological and clinical studies of derivatives over the past 20 years, which have laid the foundation for subsequent researchers to study triptolide in many ways.
Keywords: Tripterygium wilfordii, Triptolide, Biological activities, Biosynthesis, Chemical synthesis