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Theranostics 2021; 11(11):5296-5312. doi:10.7150/thno.55986 This issue Cite

Review

Role of serotonin receptor signaling in cancer cells and anti-tumor immunity

Surojit Karmakar, Girdhari Lal✉

National Centre for Cell Science (NCCS), Ganeshkhind, Pune, MH-411007, India.

✉ Corresponding author: Girdhari Lal, Ph.D. Scientist, National Centre for Cell Science, NCCS Complex, Ganeshkhind, Pune, MH-411007, India. E-mail: glalres.in; Phone: +91-20-2570-8292; Fax: +91-20-2568-2259.

Citation:
Karmakar S, Lal G. Role of serotonin receptor signaling in cancer cells and anti-tumor immunity. Theranostics 2021; 11(11):5296-5312. doi:10.7150/thno.55986. https://www.thno.org/v11p5296.htm
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Abstract

Graphic abstract

Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter known to affect emotion, behavior, and cognition, and its effects are mostly studied in neurological diseases. The crosstalk between the immune cells and the nervous system through serotonin and its receptors (5-HTRs) in the tumor microenvironment and the secondary lymphoid organs are known to affect cancer pathogenesis. However, the molecular mechanism of - alteration in the phenotype and function of - innate and adaptive immune cells by serotonin is not well explored. In this review, we discuss how serotonin and serotonin receptors modulate the phenotype and function of various immune cells, and how the 5-HT-5-HTR axis modulates antitumor immunity. Understanding how 5-HT and immune signaling are involved in tumor immunity could help improve therapeutic strategies to control cancer progression and metastasis.

Keywords: 5-hydroxytryptamine, neuroimmune communication, neurotransmitter, serotonin receptor, serotonergic system

Citation styles

APA
Karmakar, S., Lal, G. (2021). Role of serotonin receptor signaling in cancer cells and anti-tumor immunity. Theranostics, 11(11), 5296-5312. https://doi.org/10.7150/thno.55986.

ACS
Karmakar, S.; Lal, G. Role of serotonin receptor signaling in cancer cells and anti-tumor immunity. Theranostics 2021, 11 (11), 5296-5312. DOI: 10.7150/thno.55986.

NLM
Karmakar S, Lal G. Role of serotonin receptor signaling in cancer cells and anti-tumor immunity. Theranostics 2021; 11(11):5296-5312. doi:10.7150/thno.55986. https://www.thno.org/v11p5296.htm

CSE
Karmakar S, Lal G. 2021. Role of serotonin receptor signaling in cancer cells and anti-tumor immunity. Theranostics. 11(11):5296-5312.

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