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Theranostics 2021; 11(9):4090-4102. doi:10.7150/thno.53101 This issue Cite

Research Paper

Accurate in vivo tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS)

Pietro Strobbia1,2, Vanessa Cupil-Garcia1,3, Bridget M. Crawford1,2, Andrew M. Fales4, T. Joshua Pfefer4, Yang Liu1,2, Martin Maiwald5, Bernd Sumpf5, Tuan Vo-Dinh1,2,3✉

1. Fitzpatrick Institute for Photonics, Duke University, Durham, NC, USA
2. Department of Biomedical Engineering, Duke University, Durham, NC, USA
3. Department of Chemistry, Duke University, Durham, NC, USA
4. Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA
5. Ferdinand-Braun-Institut, Leibniz-Institut für Höchstfrequenztechnik, Berlin, Germany

✉ Corresponding author: tuan.vodinhedu

Citation:
Strobbia P, Cupil-Garcia V, Crawford BM, Fales AM, Pfefer TJ, Liu Y, Maiwald M, Sumpf B, Vo-Dinh T. Accurate in vivo tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS). Theranostics 2021; 11(9):4090-4102. doi:10.7150/thno.53101. https://www.thno.org/v11p4090.htm
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Abstract

Graphic abstract

For the majority of cancer patients, surgery is the primary method of treatment. In these cases, accurately removing the entire tumor without harming surrounding tissue is critical; however, due to the lack of intraoperative imaging techniques, surgeons rely on visual and physical inspection to identify tumors. Surface-enhanced Raman scattering (SERS) is emerging as a non-invasive optical alternative for intraoperative tumor identification, with high accuracy and stability. However, Raman detection requires dark rooms to work, which is not consistent with surgical settings.

Methods: Herein, we used SERS nanoprobes combined with shifted-excitation Raman difference spectroscopy (SERDS) detection, to accurately detect tumors in xenograft murine model.

Results: We demonstrate for the first time the use of SERDS for in vivo tumor detection in a murine model under ambient light conditions. We compare traditional Raman detection with SERDS, showing that our method can improve sensitivity and accuracy for this task.

Conclusion: Our results show that this method can be used to improve the accuracy and robustness of in vivo Raman/SERS biomedical application, aiding the process of clinical translation of these technologies.

Citation styles

APA
Strobbia, P., Cupil-Garcia, V., Crawford, B.M., Fales, A.M., Pfefer, T.J., Liu, Y., Maiwald, M., Sumpf, B., Vo-Dinh, T. (2021). Accurate in vivo tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS). Theranostics, 11(9), 4090-4102. https://doi.org/10.7150/thno.53101.

ACS
Strobbia, P.; Cupil-Garcia, V.; Crawford, B.M.; Fales, A.M.; Pfefer, T.J.; Liu, Y.; Maiwald, M.; Sumpf, B.; Vo-Dinh, T. Accurate in vivo tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS). Theranostics 2021, 11 (9), 4090-4102. DOI: 10.7150/thno.53101.

NLM
Strobbia P, Cupil-Garcia V, Crawford BM, Fales AM, Pfefer TJ, Liu Y, Maiwald M, Sumpf B, Vo-Dinh T. Accurate in vivo tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS). Theranostics 2021; 11(9):4090-4102. doi:10.7150/thno.53101. https://www.thno.org/v11p4090.htm

CSE
Strobbia P, Cupil-Garcia V, Crawford BM, Fales AM, Pfefer TJ, Liu Y, Maiwald M, Sumpf B, Vo-Dinh T. 2021. Accurate in vivo tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS). Theranostics. 11(9):4090-4102.

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