Theranostics 2021; 11(4):1753-1762. doi:10.7150/thno.53438 This issue Cite

Review

YAP in pancreatic cancer: oncogenic role and therapeutic strategy

Wenhao Mao1#, Jia Mai2#, Hui Peng1#, Junhu Wan1, Ting Sun1✉

1. Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
2. Department of Laboratory Medicine, West China Second Hospital, Sichuan University, Chengdu 610041, China.
#These authors contributed equally to this work.

Citation:
Mao W, Mai J, Peng H, Wan J, Sun T. YAP in pancreatic cancer: oncogenic role and therapeutic strategy. Theranostics 2021; 11(4):1753-1762. doi:10.7150/thno.53438. https://www.thno.org/v11p1753.htm
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Abstract

Graphic abstract

Pancreatic cancer, especially pancreatic ductal adenocarcinoma (PDAC), remains a fatal disease with few efficacious treatments. The Hippo signaling pathway, an evolutionarily conserved signaling module, plays critical roles in tissue homeostasis, organ size control and tumorigenesis. The transcriptional coactivator yes-associated protein (YAP), a major downstream effector of the Hippo pathway, is associated with various human cancers including PDAC. Considering its importance in cancer, YAP is emerging as a promising therapeutic target. In this review, we summarize the current understanding of the oncogenic role and regulatory mechanism of YAP in PDAC, and the potential therapeutic strategies targeting YAP.

Keywords: Pancreatic cancer, Hippo pathway, YAP, KRAS, therapeutic target


Citation styles

APA
Mao, W., Mai, J., Peng, H., Wan, J., Sun, T. (2021). YAP in pancreatic cancer: oncogenic role and therapeutic strategy. Theranostics, 11(4), 1753-1762. https://doi.org/10.7150/thno.53438.

ACS
Mao, W.; Mai, J.; Peng, H.; Wan, J.; Sun, T. YAP in pancreatic cancer: oncogenic role and therapeutic strategy. Theranostics 2021, 11 (4), 1753-1762. DOI: 10.7150/thno.53438.

NLM
Mao W, Mai J, Peng H, Wan J, Sun T. YAP in pancreatic cancer: oncogenic role and therapeutic strategy. Theranostics 2021; 11(4):1753-1762. doi:10.7150/thno.53438. https://www.thno.org/v11p1753.htm

CSE
Mao W, Mai J, Peng H, Wan J, Sun T. 2021. YAP in pancreatic cancer: oncogenic role and therapeutic strategy. Theranostics. 11(4):1753-1762.

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