1. Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. 2. Department of Laboratory Medicine, West China Second Hospital, Sichuan University, Chengdu 610041, China. #These authors contributed equally to this work.
✉ Corresponding author: Ting Sun, Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Road East, Zhengzhou 450052, China. E-mail: suntingedu.cn, Tel: +86 371-66913230.
Citation:
Mao W, Mai J, Peng H, Wan J, Sun T. YAP in pancreatic cancer: oncogenic role and therapeutic strategy. Theranostics 2021; 11(4):1753-1762. doi:10.7150/thno.53438. https://www.thno.org/v11p1753.htm
Pancreatic cancer, especially pancreatic ductal adenocarcinoma (PDAC), remains a fatal disease with few efficacious treatments. The Hippo signaling pathway, an evolutionarily conserved signaling module, plays critical roles in tissue homeostasis, organ size control and tumorigenesis. The transcriptional coactivator yes-associated protein (YAP), a major downstream effector of the Hippo pathway, is associated with various human cancers including PDAC. Considering its importance in cancer, YAP is emerging as a promising therapeutic target. In this review, we summarize the current understanding of the oncogenic role and regulatory mechanism of YAP in PDAC, and the potential therapeutic strategies targeting YAP.
Mao, W., Mai, J., Peng, H., Wan, J., Sun, T. (2021). YAP in pancreatic cancer: oncogenic role and therapeutic strategy. Theranostics, 11(4), 1753-1762. https://doi.org/10.7150/thno.53438.
ACS
Mao, W.; Mai, J.; Peng, H.; Wan, J.; Sun, T. YAP in pancreatic cancer: oncogenic role and therapeutic strategy. Theranostics 2021, 11 (4), 1753-1762. DOI: 10.7150/thno.53438.
NLM
Mao W, Mai J, Peng H, Wan J, Sun T. YAP in pancreatic cancer: oncogenic role and therapeutic strategy. Theranostics 2021; 11(4):1753-1762. doi:10.7150/thno.53438. https://www.thno.org/v11p1753.htm
CSE
Mao W, Mai J, Peng H, Wan J, Sun T. 2021. YAP in pancreatic cancer: oncogenic role and therapeutic strategy. Theranostics. 11(4):1753-1762.
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