ISSN: 1838-7640Theranostics
Global reach, higher impact
Theranostics 2020; 10(13):6011-6023. doi:10.7150/thno.38742 This issue Cite
Review
Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives
The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China
Citation:
Chen X, Yang J, Wang L, Liu B. Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives. Theranostics 2020; 10(13):6011-6023. doi:10.7150/thno.38742. https://www.thno.org/v10p6011.htm
Other stylesAbstract
Therapeutic cancer vaccines are one of the most promising strategies of immunotherapy. Traditional vaccines consisting of tumor-associated antigens have met with limited success. Recently, neoantigens derived from nonsynonymous mutations in tumor cells have emerged as alternatives that can improve tumor-specificity and reduce on-target off-tumor toxicity. Synthetic peptides are a common platform for neoantigen vaccines. It has been suggested that extending short peptides into long peptides can overcome immune tolerance and induce both CD4+ and CD8+ T cell responses. This review will introduce the history of long peptide-based neoantigen vaccines, discuss their advantages, summarize current preclinical and clinical developments, and propose future perspectives.
Keywords: Neoantigen, cancer vaccine, long peptide, solid tumor, immunotherapy
Citation styles
APA
Chen, X., Yang, J., Wang, L., Liu, B. (2020). Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives. Theranostics, 10(13), 6011-6023. https://doi.org/10.7150/thno.38742.
ACS
Chen, X.; Yang, J.; Wang, L.; Liu, B. Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives. Theranostics 2020, 10 (13), 6011-6023. DOI: 10.7150/thno.38742.
NLM
Chen X, Yang J, Wang L, Liu B. Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives. Theranostics 2020; 10(13):6011-6023. doi:10.7150/thno.38742. https://www.thno.org/v10p6011.htm
CSE
Chen X, Yang J, Wang L, Liu B. 2020. Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives. Theranostics. 10(13):6011-6023.
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.