ISSN: 1838-7640Theranostics
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Theranostics 2020; 10(11):5074-5089. doi:10.7150/thno.42441 This issue Cite
Review
3D approaches to model the tumor microenvironment of pancreatic cancer
1. Centre for Tumor Microenvironment, Barts Cancer Institute, Queen Mary University of London, EC1M 6BQ London, United Kingdom;
2. Institute of Vascular Biology, Medical University of Vienna, 1090 Vienna, Austria;
3. Department of Chemical Engineering and Department of Materials Science and Engineering, Faculty of Engineering, Monash University, Melbourne, VIC 3800, Australia;
4. Department of Anatomy and Developmental Biology, Faculty of Medicine, Monash University, Melbourne, VIC 3800, Australia.
Citation:
Tomás-Bort E, Kieler M, Sharma S, Candido JB, Loessner D. 3D approaches to model the tumor microenvironment of pancreatic cancer. Theranostics 2020; 10(11):5074-5089. doi:10.7150/thno.42441. https://www.thno.org/v10p5074.htm
Other stylesAbstract
In tumor engineering, 3D approaches are used to model components of the tumor microenvironment and to test new treatments. Pancreatic cancers are a cancer of substantial unmet need and survival rates are lower compared to any other cancer. Bioengineering techniques are increasingly applied to understand the unique biology of pancreatic tumors and to design patient-specific models. Here we summarize how extracellular and cellular elements of the pancreatic tumor microenvironment and their interactions have been studied in 3D cell cultures. We review selected clinical trials, assess the benefits of therapies interfering with the tumor microenvironment and address their limitations and future perspectives.
Citation styles
APA
Tomás-Bort, E., Kieler, M., Sharma, S., Candido, J.B., Loessner, D. (2020). 3D approaches to model the tumor microenvironment of pancreatic cancer. Theranostics, 10(11), 5074-5089. https://doi.org/10.7150/thno.42441.
ACS
Tomás-Bort, E.; Kieler, M.; Sharma, S.; Candido, J.B.; Loessner, D. 3D approaches to model the tumor microenvironment of pancreatic cancer. Theranostics 2020, 10 (11), 5074-5089. DOI: 10.7150/thno.42441.
NLM
Tomás-Bort E, Kieler M, Sharma S, Candido JB, Loessner D. 3D approaches to model the tumor microenvironment of pancreatic cancer. Theranostics 2020; 10(11):5074-5089. doi:10.7150/thno.42441. https://www.thno.org/v10p5074.htm
CSE
Tomás-Bort E, Kieler M, Sharma S, Candido JB, Loessner D. 2020. 3D approaches to model the tumor microenvironment of pancreatic cancer. Theranostics. 10(11):5074-5089.
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