Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage

Zhou, Yuyang; Xu, Ying; Lu, Lunjie; Ni, Jingyang; Nie, Jihua; Cao, Jianping; Jiao, Yang; Zhang, Qi

doi:10.7150/thno.34015

Nanotheranostics

International Journal of Biological Sciences

International Journal of Medical Sciences

Journal of Cancer

open access Global reach, higher impact

Full Text | PDF

Theranostics 2019; 9(22):6665-6675. doi:10.7150/thno.34015 This issue Cite

Research Paper

Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage

Yuyang Zhou^1✉, Ying Xu², Lunjie Lu³, Jingyang Ni¹, Jihua Nie², Jianping Cao², Yang Jiao^2✉, Qi Zhang^2✉

1. School of Chemistry, Biology and Materials Engineering, Jiangsu Key Laboratory of Environmental Functional Materials, Suzhou University of Science and Technology, Suzhou, Jiangsu, 215009, P. R. China.
2. School of Radiation Medicine and Protection, State Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu 215123, P. R. China.
3. Department of Radiation Physics, Qingdao Central Hospital, Qingdao, Shandong, 266000, P. R. China.

Citation:

Zhou Y, Xu Y, Lu L, Ni J, Nie J, Cao J, Jiao Y, Zhang Q. Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage. Theranostics 2019; 9(22):6665-6675. doi:10.7150/thno.34015. https://www.thno.org/v09p6665.htm

Other styles

Abstract

Background: Pancreatic cancer is a highly lethal malignancy which ranks 4th most common cause of cancer death in US and 6th in China. Novel drugs are required to improve the survival and prognosis of patients.

Methods: Ruthenium(II) complexes with variation number of DIP ligand were synthesized and further adopted as radiosensitizer for pancreatic cancer. The influence of ruthenium(II) complexes on cell behaviors and tumor growth were investigated. The DNA binding affinity of ruthenium(II) complexes and plasmid was measured by using agarose gel electrophoresis.

Results: Luminescent ruthenium(II) complex can rapidly enter into cell nuclei and consequently combine with DNA, resulting in the enhanced DNA damage induced by X-ray irradiation. Upon intratumoral injection of ruthenium(II) complex, excellent tumor growth inhibition was accomplished under ionizing radiation of human pancreatic cancer xenograft nude mice.

Conclusions: Taken together, our study suggest that the ruthenium(II) polypyridyl complexes can effectively enhance radiation-induced DNA damage, which is likely to benefit the imaging-guided cancer radio-chemotherapy.

Keywords: radiosensitizing, ruthenium(II), 4,7-diphenyl-1,10-phenoline, polypyridyl, pancreatic cancer.

Citation styles

APA

Zhou, Y., Xu, Y., Lu, L., Ni, J., Nie, J., Cao, J., Jiao, Y., Zhang, Q. (2019). Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage. Theranostics, 9(22), 6665-6675. https://doi.org/10.7150/thno.34015.

ACS

Zhou, Y.; Xu, Y.; Lu, L.; Ni, J.; Nie, J.; Cao, J.; Jiao, Y.; Zhang, Q. Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage. Theranostics 2019, 9 (22), 6665-6675. DOI: 10.7150/thno.34015.

NLM

CSE

Zhou Y, Xu Y, Lu L, Ni J, Nie J, Cao J, Jiao Y, Zhang Q. 2019. Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage. Theranostics. 9(22):6665-6675.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.