Theranostics 2017; 7(18):4551-4565. doi:10.7150/thno.19782 This issue


Quantitative Imaging for Targeted Radionuclide Therapy Dosimetry - Technical Review

Tiantian Li1, Edwin C. I. Ao1, Bieke Lambert2,3, Boudewijn Brans4, Stefaan Vandenberghe5✉, Greta S. P. Mok1,6✉

1. Biomedical Imaging Laboratory, Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau SAR, China;
2. Dept of Radiology and Nuclear medicine, Ghent University, De Pintelaan 185 9000 Gent, Belgium;
3. AZ Maria Middelares, Buiten-Ring-Sint-Denijs 30, 9000 Gent, Belgium;
4. Dept of Nuclear Medicine, UZ Ghent-Ghent University, St-Pietersnieuwstraat 41, 9000 Gent, Belgium;
5. MEDISIP-ELIS-IBITECH-IMEC, Ghent University, St-Pietersnieuwstraat 41, 9000 Gent, Belgium;
6. Faculty of Health Sciences, University of Macau, Macau SAR, China.

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Li T, Ao ECI, Lambert B, Brans B, Vandenberghe S, Mok GSP. Quantitative Imaging for Targeted Radionuclide Therapy Dosimetry - Technical Review. Theranostics 2017; 7(18):4551-4565. doi:10.7150/thno.19782. Available from

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Graphic abstract

Targeted radionuclide therapy (TRT) is a promising technique for cancer therapy. However, in order to deliver the required dose to the tumor, minimize potential toxicity in normal organs, as well as monitor therapeutic effects, it is important to assess the individualized internal dosimetry based on patient-specific data. Advanced imaging techniques, especially radionuclide imaging, can be used to determine the spatial distribution of administered tracers for calculating the organ-absorbed dose. While planar scintigraphy is still the mainstream imaging method, SPECT, PET and bremsstrahlung imaging have promising properties to improve accuracy in quantification. This article reviews the basic principles of TRT and discusses the latest development in radionuclide imaging techniques for different theranostic agents, with emphasis on their potential to improve personalized TRT dosimetry.

Keywords: Nuclear medicine imaging, targeted radionuclide therapy, internal dosimetry, theranostic agents.