Theranostics 2017; 7(13):3207-3227. doi:10.7150/thno.19738 This issue


Iron Oxide Nanozyme: A Multifunctional Enzyme Mimetic for Biomedical Applications

Lizeng Gao1, 2✉, Kelong Fan2, Xiyun Yan2, 3✉

1. Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225001, China;
2. Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;
3. University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, China.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license ( See for full terms and conditions.
Gao L, Fan K, Yan X. Iron Oxide Nanozyme: A Multifunctional Enzyme Mimetic for Biomedical Applications. Theranostics 2017; 7(13):3207-3227. doi:10.7150/thno.19738. Available from

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Graphic abstract

Iron oxide nanoparticles have been widely used in many important fields due to their excellent nanoscale physical properties, such as magnetism/superparamagnetism. They are usually assumed to be biologically inert in biomedical applications. However, iron oxide nanoparticles were recently found to also possess intrinsic enzyme-like activities, and are now regarded as novel enzyme mimetics. A special term, “Nanozyme”, has thus been coined to highlight the intrinsic enzymatic properties of such nanomaterials. Since then, iron oxide nanoparticles have been used as nanozymes to facilitate biomedical applications. In this review, we will introduce the enzymatic features of iron oxide nanozyme (IONzyme), and summarize its novel applications in biomedicine.

Keywords: Iron oxide, Enzyme-like activities, Nanozyme, Enzyme mimetics, Biomedical applications.