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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

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Research Paper
Sex- and age-specific sensitivities of the endocannabinoid system in Alzheimer's disease revealed by PET imaging with [18F]FMPEP-d2 and [18F]MAGL-2102
Anna Pees, Christopher Daniel Morrone, Junchao Tong, Jian Rong, Tuo Shao, Darcy Wear, Steven H. Liang, Wai Haung Yu, Neil Vasdev
Theranostics 2025; 15(8): 3368-3385. doi:10.7150/thno.106592
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Review
Supercharging CAR-T cells through transcriptional and epigenetic armoring
Diyuan Qin, Yanna Lei, Pei Shu, Yugu Zhang, Yuin-Han Loh, Yongsheng Wang, Qijing Li
Theranostics 2025; 15(8): 3345-3367. doi:10.7150/thno.107908
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Review
Antigen-presenting fibroblasts: emerging players in immune modulation and therapeutic targets
Xiaoyun Chen, Fangqi Chen, Sujie Jia, Qianjin Lu, Ming Zhao
Theranostics 2025; 15(8): 3332-3344. doi:10.7150/thno.104900
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Research Paper
PBRM1 deficiency enhances PD1 immunotherapeutic sensitivity via chromosomal accessibility in colorectal cancer
Rui Li, Jie He, Chaoqun Liu, Zesheng Jiang, Jiasheng Qin, Kun Liang, Zhuocheng Ji, Liang Zhao
Theranostics 2025; 15(8): 3316-3331. doi:10.7150/thno.100793
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Review
Engineered Probiotic-Based Biomaterials for Inflammatory Bowel Disease Treatment
Guangze Sang, Bingkai Wang, Yujie Xie, Yu Chen, Feng Yang
Theranostics 2025; 15(8): 3289-3315. doi:10.7150/thno.103983
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Research Paper
SPEAR: CRISPR-mediated ultrasensitive, specific and rapid one-pot detection strategy for cancer-related SNPs
Linlin Bai, Yanan Pang, Ting Wang, Shengzhou Wang, Kaiming Guo, Tian Xuan, Ziqin Zhang, Dianwei Liu, Feng Qian, Yan Zheng, Gang Jin, Rui Wang
Theranostics 2025; 15(8): 3275-3288. doi:10.7150/thno.107488
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Founding Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
EIC profile

Congratulations! Professor Chen has been elected as a member of the Academia Europaea.

newTheranostics is seeking a new Editor-in-Chief. Read announcement

Antigen-presenting fibroblasts are a newly recognized subset that challenges the traditional view of these cells as mere structural components. Under pathological or environmental stimuli, fibroblasts acquire antigen-presenting capabilities through the expression of MHC-II molecules and co-stimulatory factors, enabling them to interact with T cells and modulate immune responses. These specialized fibroblasts have been identified across various tissues and diseases, where they play context-dependent roles, either amplifying immune dysregulation or contributing to immune homeostasis. This review....
Inspired by the remarkable success of CAR-T therapy in hematologic malignancies, research is increasingly focused on adapting this treatment for solid tumors. However, CAR-T efficacy remains limited due to its exhaustion and shortened persistence. Transcription factors and epigenetic modifications play pivotal roles in modulating T cell differentiation and functionality, which have been leveraged in numerous strategies to promote the formation of long-lasting memory cells with stem-like properties and supercharging CAR-T performance. This review highlights pivotal transcriptional factors, such....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Structural Dynamics of OATP1A2 in Mediating Paclitaxel Transport Mechanism in Breast Cancer
Rohit Kumar, Garima Singh, Yusuf Akhter, Gaurav Kaithwas, Ashish Kumar Agrawal, Sanjay Singh
Nanotheranostics 2025; 9(1): 52-62.
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