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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

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Research Paper
Histone lactylation-driven B7-H3 expression promotes tumor immune evasion
Zhibo Ma, Jincui Yang, Wenlong Jia, Le Li, Yixin Li, Junjie Hu, Wei Luo, Ronghui Li, Dawei Ye, Peixiang Lan
Theranostics 2025; 15(6): 2338-2359. doi:10.7150/thno.105947
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Research Paper
Neural mechanism of trigeminal nerve stimulation recovering defensive arousal responses in traumatic brain injury
Qian Zhang, Haiyun Ma, Lifang Huo, Shaoling Wang, Qian Yang, Zhimin Ye, Jie Cao, Shaoling Wu, Chao Ma, Congping Shang
Theranostics 2025; 15(6): 2315-2337. doi:10.7150/thno.106323
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Research Paper
USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5
Xiao Zhou, Qiaoxi Xia, Botao Wang, Junjun Li, Bing Liu, Sisi Wang, Min Huang, Ronghui Zhong, Shi-Yuan Cheng, Xuan Wang, Xiaobing Jiang, Tianzhi Huang
Theranostics 2025; 15(6): 2293-2314. doi:10.7150/thno.103629
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Research Paper
Neurotrophic factor-α1/carboxypeptidase E controls progression and reversal of Alzheimer's disease pathogenesis in mice
Fang-Cheng Fan, Li-Ming Liu, Mei Guo, Yang Du, Yue-Wen Chen, Y. Peng Loh, Yong Cheng
Theranostics 2025; 15(6): 2279-2292. doi:10.7150/thno.99908
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Review
Epigenetic regulation-mediated disorders in dopamine transporter endocytosis: A novel mechanism for the pathogenesis of Parkinson's disease
Ziqi Liang, Wanqing Liu, Mian Cao, Jiajun Cui, Jinshuai Lan, Yue Ding, Tong Zhang, Zizhao Yang
Theranostics 2025; 15(6): 2250-2278. doi:10.7150/thno.107436
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Research Paper
Extracellular matrix proteins refine microenvironments for pancreatic organogenesis from induced pluripotent stem cell differentiation
Ming Hu, Tianzheng Liu, Hui Huang, Derek Ogi, Yinfei Tan, Kaiming Ye, Sha Jin
Theranostics 2025; 15(6): 2229-2249. doi:10.7150/thno.104883
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

Congratulations! Professor Chen has been elected as a member of the Academia Europaea.

Background: Neurotrophic Factor-α1/Carboxypeptidase E (NF-α1/CPE) is a pivotal neuroprotective protein implicated in rescuing cognitive decline associated with Alzheimer's disease (AD). However, its direct role in AD pathogenesis remains unexplored. Methods: We utilized the Cre/LoxP system to diminish NF-α1/CPE expression, and employed AAV-mediated overexpression of NF-α1/CPE. Results: NF-α1/CPE expression was significantly down-regulated in advanced stages of AD and with age in 5xFAD mice. Reduced NF-α1/CPE levels in the hippocampus of 5xFAD mice increased plaque....
Mechanisms such as DNA methylation, histone modifications, and non-coding RNA regulation may impact the endocytosis of dopamine transporter (DAT) by influencing processes like neuronal survival, thereby contributing to the initiation and progression of Parkinson's Disease (PD). Some small molecule inhibitors or natural bioactive compounds have the potential to modulate epigenetic processes, thereby reversing induced pluripotent stem cells (iPSCs) reprogramming and abnormal differentiation, offering potential therapeutic effects for PD. Although no specific DNA modification enzyme directly regulates....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Therapeutic Potential of Feline Adipose-Derived Stem Cell Exosomes in the Treatment of Feline Idiopathic Cystitis: A Characterization and Functional Analysis of miRNA Content
Andrea Rubini, Federica Zanotti, Danilo Licastro, Giulia Calogero, Gisella Bettini, Cristiana Piccoli, Giuseppe Rubini, Luca Lovatti, Barbara Zavan
Nanotheranostics 2025; 9(1): 38-51.
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