Review Micro/nanorobotics for sepsis diagnosis and therapy: a frontier in precision medicine Full text PDF
Research Paper PEGylated IL2 and tumor-targeted radiotherapy augment CD8+ T cell-mediated anti-tumor response to anti-PD-1 in head and neck squamous cell carcinoma Full text PDF
Research Paper Targeting USP22 reprograms the tumor microenvironment and sensitizes KRAS/p53-driven lung cancer to anti-PD-1 immunotherapy Full text PDF
Research Paper Cardiomyocyte-Specific RNF128 Attenuates Pathological Cardiac Hypertrophy Progression by Stabilizing SERCA2a through Lys63-Linked Polyubiquitination Full text PDF
Research Paper Mapping endometrial vascular functional gradients using depth-derived ultrasound localization microscopy (D-ULM) for early stratification of postinjury fibrotic remodeling and therapeutic guidance Full text PDF
Research Paper Lactylation at H3K18 drives pathological angiogenesis via metabolic-epigenetic crosstalk in ischemic retinopathy Full text PDF
Issue 13; 2026
Founding Editor-in-Chief:
Prof. Xiaoyuan (Shawn) Chen, PhD
Profile
Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.
Combination of immune checkpoint inhibitors (ICI) with either radiotherapy or PEGylated interleukin 2 (pegIL2) has produced limited or no benefits over ICI alone in clinical trials. A triple combination of radiotherapy, pegIL2, and ICI may overcome the limitations of dual treatments. We report a phase II clinical trial evaluating tumor-targeted radiotherapy, pegIL2 (BEMPEG), and ICI (pembrolizumab) in patients with recurrent or metastatic head and ...