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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

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Research Paper
Palladium-103 (103Pd/103mRh), a promising Auger-electron emitter for targeted radionuclide therapy of disseminated tumor cells - absorbed doses in single cells and clusters, with comparison to 177Lu and 161Tb
Elif Hindié, Alexandre Larouze, Mario Alcocer-Ávila, Clément Morgat, Christophe Champion
Theranostics 2024; 14(11): 4318-4330. doi:10.7150/thno.95436
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Research Paper
Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation
Xiao-Yi Xiong, Xin-Ru Pan, Xia-Xia Luo, Yu-Fei Wang, Xin-Xiao Zhang, Su-Hao Yang, Zhan-Qiong Zhong, Chang Liu, Qiong Chen, Peng-Fei Wang, Xiao-Wei Chen, Shu-Guang Yu, Qing-Wu Yang
Theranostics 2024; 14(11): 4297-4317. doi:10.7150/thno.96375
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Research Paper
Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis
Ning Li, Lei Zhao, Xinyu Geng, Jingyang Liu, Xu Zhang, Ying Hu, Jihan Qi, Hongliang Chen, Jiawei Qiu, Xiaoyu Zhang, Shizhu Jin
Theranostics 2024; 14(11): 4278-4296. doi:10.7150/thno.96038
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Research Paper
Methyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis
Liangqi Chen, Meiju Zhang, Xueyan Yang, Yanan Wang, Tuo Huang, Xin Li, Yunting Ban, Qifeng Li, Qingyuan Yang, Yongxiang Zhang, Yang Zheng, Di Wang, Xiaoqi Wang, Xiujie Shi, Maomao Zhang, Yong Sun, Jian Wu
Theranostics 2024; 14(11): 4256-4277. doi:10.7150/thno.94738
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Research Paper
Pioneering noninvasive colorectal cancer detection with an AI-enhanced breath volatilomics platform
Yongqian Liu, Yongyan Ji, Jian Chen, Yixuan Zhang, Xiaowen Li, Xiang Li
Theranostics 2024; 14(11): 4240-4255. doi:10.7150/thno.94950
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Research Paper
Aryl hydrocarbon receptor confers protection against macrophage pyroptosis and intestinal inflammation through regulating polyamine biosynthesis
Yajing Gao, Kwei-Yan Liu, Wenfeng Xiao, Xueru Xie, Qiuyan Liang, Zikun Tu, Lan Yang, Hongmiao Yu, Haiyan Guo, Saihua Huang, Xiao Han, Jinrong Fu, Yufeng Zhou
Theranostics 2024; 14(11): 4218-4239. doi:10.7150/thno.95749
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Review
Multifunctional hydrogel-based engineered extracellular vesicles delivery for complicated wound healing
Zuhao Li, Jinlong Liu, Jian Song, Zhifeng Yin, Fengjin Zhou, Hao Shen, Guangchao Wang, Jiacan Su
Theranostics 2024; 14(11): 4198-4217. doi:10.7150/thno.97317
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Research Paper
68Ga-labeled fibroblast activation protein inhibitor (FAPI) PET/CT for locally advanced or recurrent pancreatic cancer staging and restaging after chemoradiotherapy
Giulia Metzger, Christian Bayerl, Julian MM Rogasch, Christian Furth, Christoph Wetz, Marcus Beck, Felix Mehrhof, Holger Amthauer, Pirus Ghadjar, Christopher Neumann, Uwe Pelzer, Daniel Zips, Frank Hofheinz, Jane Grabowski, Imke Schatka, Sebastian Zschaeck
Theranostics 2024; 14(11): 4184-4197. doi:10.7150/thno.95329
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Congratulations! Professor Chen has been elected as a member of the Academia Europaea.

CFP - Special issue on Molecular Imaging and Theranostics. Guest Editors: Dr. Jianhua Zou, Dr. Jingjing Zhang and Dr. Mengyao Zhao.

Rationale: The aryl hydrocarbon receptor (AhR) functions in the regulation of intestinal inflammation, but knowledge of the underlying mechanisms in innate immune cells is limited. Here, we investigated the role of AhR in modulating the functions of macrophages in inflammatory bowel disease pathogenesis. Methods: The cellular composition of intestinal lamina propria CD45+ leukocytes in a dextran sulfate sodium (DSS)-induced mouse colitis model was determined by single-cell RNA sequencing. Macrophage pyroptosis was quantified by analysis of lactate dehydrogenase release, propidium iodide staining,....
Rationale: Posttranslational modifications of proteins have not been addressed in studies aimed at elucidating the cardioprotective effect of exercise in atherosclerotic cardiovascular disease (ASCVD). In this study, we reveal a novel mechanism by which exercise ameliorates atherosclerosis via lactylation. Methods: Using ApoE-/- mice in an exercise model, proteomics analysis was used to identify exercise-induced specific lactylation of MeCP2 at lysine 271 (K271). Mutation of the MeCP2 K271 lactylation site in aortic plaque macrophages was achieved by recombinant adenoviral transfection. Explore....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Neuroprotective Effects of Zinc Oxide Nanoparticles in a Rotenone-Induced Mouse Model of Parkinson's Disease
Yasmeen Khafajah, Mariam Shaheen, Dania El Natour, Maxime Merheb, Rachel Matar, Jamilah Borjac
Nanotheranostics 2024; 8(4): 497-505.
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