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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

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Research Paper
Macrophage membrane‒biomimetic nanoparticles target inflammatory microenvironment for epilepsy treatment
Chao Geng, Xinghui Ren, Peipei Cao, Xiaoqi Chu, Penghu Wei, Quanlei Liu, Yongchang Lu, Bin Fu, Wenyou Li, Yuhao Li, Guoguang Zhao
Theranostics 2024; 14(17): 6652-6670. doi:10.7150/thno.99260
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Research Paper
Brain-to-heart cholinergic synapse-calcium signaling mediates ischemic stroke-induced atrial fibrillation
Yingran Liang, Gongxin Wang, Siwen Fan, Junyi Zhang, Shuang He, Guixiang Pan, Guoliang Hao, Yan Zhu
Theranostics 2024; 14(17): 6625-6651. doi:10.7150/thno.99065
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Research Paper
Hypothalamic P62 (SQSTM1) regulates energy balance by modulating leptin signaling
Shan Yang, Yang Li, Mingyuan Tian, Wuquan Deng, Dongfang Liu, Chen Chen, Zhiming Zhu, Hongting Zheng, Gangyi Yang, Ling Li, Mengliu Yang
Theranostics 2024; 14(17): 6605-6624. doi:10.7150/thno.96480
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Research Paper
Tumor-derived EV miRNA signatures surpass total EV miRNA in supplementing mammography for precision breast cancer diagnosis
Young Kim, Jee Ye Kim, Sol Moon, Hyojung Lee, Suji Lee, Joon Ye Kim, Min Woo Kim, Seung Il Kim
Theranostics 2024; 14(17): 6587-6604. doi:10.7150/thno.99245
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Research Paper
Biomineralized in situ catalytic nanoreactor integrated microneedle patch for on demand immunomodulator supply to combat psoriasis
Xiaodie Li, Minglong Chen, Xinni He, Jinghang Cong, Wanchen Zhao, Yanping Fu, Chao Lu, Chuanbin Wu, Xin Pan, Guilan Quan
Theranostics 2024; 14(17): 6571-6586. doi:10.7150/thno.101845
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Research Paper
Supramolecularly engineered bacteria mediated calcium overload and immunotherapy of tumors
Beibei Xie, Linmiao Dong, Leo Wang, Ruibing Wang, Chunlai Li
Theranostics 2024; 14(17): 6560-6570. doi:10.7150/thno.99931
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

new Congratulations! Professor Chen has been elected as a member of the Academia Europaea.

Background: With the rising global incidence and mortality rates of breast cancer, early diagnosis is becoming increasingly crucial. The World Health Organization (WHO) recommends mammography as a primary screening tool. However, despite its clinical benefits, mammography has potential risks including radiation exposure, unnecessary follow-up, and overdiagnosis due to false positives, particularly in cases of early cancer or dense breast tissue. In this study, we aimed to address these concerns by introducing an innovative diagnostic method that employs circulating biomarkers to enhance the existing....
Rationale: The multifaceted functions of p62 (SQSTM1) are increasingly recognized, but its role in hypothalamic metabolism-associated neurons for energy balance has yet to be elucidated. Methods: Single-nucleus RNA sequencing (snRNA-Seq) was performed on hypothalamic tissues from db/db and db/m mice to explore p62 expression. Overexpression and knockout of p62 in hypothalamic POMC neurons were performed via AAV-mediated gene delivery and Cre-loxP systems. Metabolic outcomes were assessed under normal chow (NCD) and high-fat diet (HFD) conditions. The co-immunoprecipitation and luciferase reporter....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Unraveling In vivo Potential of Curcumin-loaded Graphene Quantum Dots on Drug Delivery and Release Kinetics Aspects of Cancer Treatment
Mochamad Z. Fahmi, Siti F. A. Sugito, Aswandi Wibrianto, Siska Novania, Shinta Widyastuti, Musbahu Adam Ahmad, Satya C. W. Sakti, Lee H. Voon
Nanotheranostics 2024; 8(4): 521-534.
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