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Volume 8 (17); 2018

Research Papers

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Combination of NIR therapy and regulatory T cell modulation using layer-by-layer hybrid nanoparticles for effective cancer photoimmunotherapy
Wenquan Ou, Liyuan Jiang, Raj Kumar Thapa, Zar Chi Soe, Kishwor Poudel, Jae-Hoon Chang, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Theranostics 2018; 8(17): 4574-4590. doi:10.7150/thno.26758
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Radiopaque and uniform alginate microspheres loaded with tantalum nanoparticles for real-time imaging during transcatheter arterial embolization
Jian Zeng, Ling Li, Hongsen Zhang, Jianye Li, Lingli Liu, Guofeng Zhou, Qing Du, Chuansheng Zheng, Xiangliang Yang
Theranostics 2018; 8(17): 4591-4600. doi:10.7150/thno.27379
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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ATP-activated decrosslinking and charge-reversal vectors for siRNA delivery and cancer therapy
Zhanwei Zhou, Qingyan Zhang, Minghua Zhang, Huipeng Li, Gang Chen, Chenggen Qian, David Oupicky, Minjie Sun
Theranostics 2018; 8(17): 4604-4619. doi:10.7150/thno.26889
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Senescent fibroblasts drive ageing pigmentation: ​A potential therapeutic target for senile lentigo
Jung Eun Yoon, Yeongeun Kim, Soohyun Kwon, Misun Kim, Young Hwa Kim, Jang-Hee Kim, Tae Jun Park, Hee Young Kang
Theranostics 2018; 8(17): 4620-4632. doi:10.7150/thno.26975
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Aphthous ulcer drug inhibits prostate tumor metastasis by targeting IKKɛ/TBK1/NF-κB signaling
Chaping Cheng, Zhongzhong Ji, Yaru Sheng, Jinming Wang, Yujiao Sun, Huifang Zhao, Xiaoxia Li, Xue Wang, Yuman He, Jufang Yao, Li Wang, Chenlu Zhang, Yanjing Guo, Jianming Zhang, Wei-Qiang Gao, Helen He Zhu
Theranostics 2018; 8(17): 4633-4648. doi:10.7150/thno.26687
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Hypoxia-induced up-regulation of VASP promotes invasiveness and metastasis of hepatocellular carcinoma
Zhikui Liu, Yufeng Wang, Changwei Dou, Meng Xu, Liankang Sun, Liang Wang, Bowen Yao, Qing Li, Wei Yang, Kangsheng Tu, Qingguang Liu
Theranostics 2018; 8(17): 4649-4663. doi:10.7150/thno.26789
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling
Laurel A. Grisanti, Toby P. Thomas, Rhonda L. Carter, Claudio de Lucia, Erhe Gao, Walter J. Koch, Jeffrey L. Benovic, Douglas G. Tilley
Theranostics 2018; 8(17): 4664-4678. doi:10.7150/thno.26619
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dopaminergic precursors differentiated from human blood-derived induced neural stem cells improve symptoms of a mouse Parkinson's disease model
Yanpeng Yuan, Xihe Tang, Yun-Fei Bai, Shuyan Wang, Jing An, Yanchuan Wu, Zhi-Qing David Xu, Y. Alex Zhang, Zhiguo Chen
Theranostics 2018; 8(17): 4679-4694. doi:10.7150/thno.26643
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Gαi1 and Gαi3mediate VEGF-induced VEGFR2 endocytosis, signaling and angiogenesis
Jian Sun, Wei Huang, Shuo-fei Yang, Xiao-pei Zhang, Qing Yu, Zhi-qing Zhang, Jin Yao, Ke-ran Li, Qin Jiang, Cong Cao
Theranostics 2018; 8(17): 4695-4709. doi:10.7150/thno.26203
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches
Julian Bejarano, Mario Navarro-Marquez, Francisco Morales-Zavala, Javier O. Morales, Ivonne Garcia-Carvajal, Eyleen Araya-Fuentes, Yvo Flores, Hugo E. Verdejo, Pablo F. Castro, Sergio Lavandero, Marcelo J. Kogan
Theranostics 2018; 8(17): 4710-4732. doi:10.7150/thno.26284
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-β pathway
Qixue Wang, Jinquan Cai, Chuan Fang, Chao Yang, Junhu Zhou, Yanli Tan, Yunfei Wang, Yansheng Li, Xiangqi Meng, Kai Zhao, Kaikai Yi, Sijing Zhang, Jianning Zhang, Chuanlu Jiang, Jing Zhang, Chunsheng Kang
Theranostics 2018; 8(17): 4733-4749. doi:10.7150/thno.26550
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis
Chantal J.M. van Opbergen, Charlotte D. Koopman, Bart J.M. Kok, Thomas Knöpfel, Sabine L. Renninger, Michael B. Orger, Marc A. Vos, Toon A.B. van Veen, Jeroen Bakkers, Teun P. de Boer
Theranostics 2018; 8(17): 4750-4764. doi:10.7150/thno.26108
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized 13C-MRSI
Christian Hundshammer, Miriam Braeuer, Christoph A. Müller, Adam E. Hansen, Mathias Schillmaier, Stephan Düwel, Benedikt Feuerecker, Steffen J. Glaser, Axel Haase, Wilko Weichert, Katja Steiger, Jorge Cabello, Franz Schilling, Jan-Bernd Hövener, Andreas Kjær, Stephan G. Nekolla, Markus Schwaiger
Theranostics 2018; 8(17): 4765-4780. doi:10.7150/thno.25162
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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RGS4 deficit in prefrontal cortex contributes to the behaviors related to schizophrenia via system xc--mediated glutamatergic dysfunction in mice
Min-Wei Huang, Yu-Jung Lin, Chi-Wei Chang, Fu-Ju Lei, En-Peng Ho, Ren-Shyan Liu, Woei-Cherng Shyu, Chia-Hung Hsieh
Theranostics 2018; 8(17): 4781-4794. doi:10.7150/thno.25189
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Inhibition of Notch1 induces population and suppressive activity of regulatory T cell in inflammatory arthritis
Bo Youn Choi, Yuri Choi, Jong-Sung Park, Li-Jung Kang, Seung Hyun Baek, Jin Su Park, Gahee Bahn, Yoonsuk Cho, Hark Kyun Kim, Jihoon Han, Jae Hoon Sul, Sang-Ha Baik, Dong Hoon Hyun, Thiruma V. Arumugam, Siyoung Yang, Jeung-Whan Han, Young Mo Kang, Yong-Woo Cho, Jae Hyung Park, Dong-Gyu Jo
Theranostics 2018; 8(17): 4795-4804. doi:10.7150/thno.26093
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
Céline S. Gonçalves, Joana Vieira de Castro, Marta Pojo, Eduarda P. Martins, Sandro Queirós, Emmanuel Chautard, Ricardo Taipa, Manuel Melo Pires, Afonso A. Pinto, Fernando Pardal, Carlos Custódia, Cláudia C. Faria, Carlos Clara, Rui M. Reis, Nuno Sousa, Bruno M. Costa
Theranostics 2018; 8(17): 4805-4823. doi:10.7150/thno.25025
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Neurogliovascular dysfunction in a model of repeated traumatic brain injury
Conner Adams, Paolo Bazzigaluppi, Tina L. Beckett, Jossana Bishay, Iliya Weisspapir, Adrienne Dorr, James R. Mester, Joe Steinman, Lydiane Hirschler, Jan M. Warnking, Emmanuel L. Barbier, JoAnne McLaurin, John G. Sled, Bojana Stefanovic
Theranostics 2018; 8(17): 4824-4836. doi:10.7150/thno.24747
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MRI and histological evaluation of pulsed focused ultrasound and microbubbles treatment effects in the brain
Zsofia I Kovacs, Tsang-Wei Tu, Maggie Sundby, Farhan Qureshi, Bobbi K Lewis, Neekita Jikaria, Scott R Burks, Joseph A Frank
Theranostics 2018; 8(17): 4837-4855. doi:10.7150/thno.24512
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Evaluation of antibody fragment properties for near-infrared fluorescence imaging of HER3-positive cancer xenografts
Ayman El-Sayed, Wendy Bernhard, Kris Barreto, Carolina Gonzalez, Wayne Hill, Landon Pastushok, Humphrey Fonge, C. Ronald Geyer
Theranostics 2018; 8(17): 4856-4869. doi:10.7150/thno.24252
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Erratum

Early Assessment of Tumor Response to Radiation Therapy using High-Resolution Quantitative Microvascular Ultrasound Imaging: Erratum
Sandeep K. Kasoji, Judith N. Rivera, Ryan C. Gessner, Sha X. Chang, Paul A. Dayton
Theranostics 2018; 8(17): 4601-4603. doi:10.7150/thno.28837
[Abstract] [Full text] [PDF] [PubMed] [PMC]