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Volume 8 (16); 2018

Research Papers

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Comparative biodistribution analysis across four different 89Zr-monoclonal antibody tracers—The first step towards an imaging warehouse
Frederike Bensch, Michaël M. Smeenk, Suzanne C. van Es, Johan R. de Jong, Carolina P. Schröder, Sjoukje F. Oosting, Marjolijn N. Lub-de Hooge, C. Willemien Menke-van der Houven van Oordt, Adrienne H. Brouwers, Ronald Boellaard, Elisabeth G.E. de Vries
Theranostics 2018; 8(16): 4295-4304. doi:10.7150/thno.26370
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cholangiocarcinoma therapy with nanoparticles that combine downregulation of MicroRNA-210 with inhibition of cancer cell invasiveness
Ying Xie, Yazhe Wang, Jing Li, Yu Hang, Lee Jaramillo, Cody J. Wehrkamp, Mary Anne Phillippi, Ashley M. Mohr, Yi Chen, Geoffrey A. Talmon, Justin L. Mott, David Oupický
Theranostics 2018; 8(16): 4305-4320. doi:10.7150/thno.26506
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Intragland Shh gene delivery mitigated irradiation-induced hyposalivation in a miniature pig model
Liang Hu, Zhao Zhu, Bo Hai, Shimin Chang, Linsha Ma, Yipu Xu, Xiangchun Li, Xiaoyu Feng, Xiaoshan Wu, Qingguo Zhao, Lizheng Qin, Jingsong Wang, Chunmei Zhang, Fei Liu, Songlin Wang
Theranostics 2018; 8(16): 4321-4331. doi:10.7150/thno.26509
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Aptamer-functionalized nanoscale metal-organic frameworks for targeted photodynamic therapy
Hong-Min Meng, Xiao-Xiao Hu, Ge-Zhi Kong, Chan Yang, Ting Fu, Zhao-Hui Li, Xiao-Bing Zhang
Theranostics 2018; 8(16): 4332-4344. doi:10.7150/thno.26768
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Transcriptomic signature associated with carcinogenesis and aggressiveness of papillary thyroid carcinoma
Huajing Teng, Fengbiao Mao, Jialong Liang, Meiying Xue, Wenqing Wei, Xianfeng Li, Kun Zhang, Dongdong Feng, Baoguo Liu, Zhongsheng Sun
Theranostics 2018; 8(16): 4345-4358. doi:10.7150/thno.26862
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival
Wu Zhang, Chen Zhao, Junmei Zhao, Yongmei Zhu, Xiangqin Weng, Qiusheng Chen, Huiping Sun, Jian-Qing Mi, Junmin Li, Jiang Zhu, Zhu Chen, Pier Paolo Pandolfi, Saijuan Chen, Xiaojing Yan, Jie Xu
Theranostics 2018; 8(16): 4359-4371. doi:10.7150/thno.26900
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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3D printing of Mo-containing scaffolds with activated anabolic responses and bi-lineage bioactivities
Wentao Dang, Xiaoya Wang, Jiayi Li, Cuijun Deng, Yaqin Liu, Qingqiang Yao, Liming Wang, Jiang Chang, Chengtie Wu
Theranostics 2018; 8(16): 4372-4392. doi:10.7150/thno.27088
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1
Ki Cheon Kim, Jaesuk Yun, Dong Ju Son, Ji Young Kim, Jae-Kyung Jung, Jeong Soon Choi, Yu Ri Kim, Ju Kyung Song, Sun Young Kim, Sin Kook Kang, Dae Hwan Shin, Yoon-Seok Roh, Sang-Bae Han, Jin Tae Hong
Theranostics 2018; 8(16): 4409-4428. doi:10.7150/thno.26467
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Novel multi-drug delivery hydrogel using scar-homing liposomes improves spinal cord injury repair
Qingqing Wang, Hongyu Zhang, Helin Xu, Yingzheng Zhao, Zhengmao Li, Jiawei Li, Haoli Wang, Deli Zhuge, Xin Guo, Huazi Xu, Salazar Jones, Xiaokun Li, Xiaofeng Jia, Jian Xiao
Theranostics 2018; 8(16): 4429-4446. doi:10.7150/thno.26717
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Aspirin cooperates with p300 to activate the acetylation of H3K9 and promote FasL-mediated apoptosis of cancer stem-like cells in colorectal cancer
Zhigang Chen, Wenlu Li, Fuming Qiu, Qi Huang, Zhou Jiang, Jun Ye, Pu Cheng, Cho Low, Yikun Guo, Xinchi Yi, Wenteng Chen, Yongpin Yu, YueHua Han, Jun Wu, Shenghang Jin, Dong Kong, Jian Huang
Theranostics 2018; 8(16): 4447-4461. doi:10.7150/thno.24284
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model
Bogdan Mitran, Rezan Güler, Francis P. Roche, Elin Lindström, Ram Kumar Selvaraju, Filippa Fleetwood, Sara S. Rinne, Lena Claesson-Welsh, Vladimir Tolmachev, Stefan Ståhl, Anna Orlova, John Löfblom
Theranostics 2018; 8(16): 4462-4476. doi:10.7150/thno.24395
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Integration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis
Stephanie Herman, Payam Emami Khoonsari, Andreas Tolf, Julia Steinmetz, Henrik Zetterberg, Torbjörn Åkerfeldt, Per-Johan Jakobsson, Anders Larsson, Ola Spjuth, Joachim Burman, Kim Kultima
Theranostics 2018; 8(16): 4477-4490. doi:10.7150/thno.26249
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Therapeutic mesopore construction on 2D Nb2C MXenes for targeted and enhanced chemo-photothermal cancer therapy in NIR-II biowindow
Xiaoxia Han, Xiangxiang Jing, Dayan Yang, Han Lin, Zhigang Wang, Haitao Ran, Pan Li, Yu Chen
Theranostics 2018; 8(16): 4491-4508. doi:10.7150/thno.26291
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CD28null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death
Alejandra Pera, Stefano Caserta, Fabio Albanese, Pinar Blowers, George Morrow, Nadia Terrazzini, Helen E Smith, Chakravarthi Rajkumar, Bernhard Reus, James R Msonda, Murielle Verboom, Michael Hallensleben, Rainer Blasczyk, Kevin A Davies, Florian Kern
Theranostics 2018; 8(16): 4509-4519. doi:10.7150/thno.27428
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Rewiring of cisplatin-resistant bladder cancer cells through epigenetic regulation of genes involved in amino acid metabolism
Austin Yeon, Sungyong You, Minhyung Kim, Amit Gupta, Myung Hee Park, Daniel J. Weisenberger, Gangning Liang, Jayoung Kim
Theranostics 2018; 8(16): 4520-4534. doi:10.7150/thno.25130
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Liver-heart crosstalk controls IL-22 activity in cardiac protection after myocardial infarction
Ting-Ting Tang, Yuan-Yuan Li, Jing-Jing Li, Ke Wang, Yue Han, Wen-Yong Dong, Zheng-Feng Zhu, Ni Xia, Shao-Fang Nie, Min Zhang, Zhi-Peng Zeng, Bing-Jie Lv, Jiao Jiao, Heng Liu, Zong-Shu Xian, Xiang-Ping Yang, Yu Hu, Yu-Hua Liao, Qing Wang, Xin Tu, Ziad Mallat, Yu Huang, Guo-Ping Shi, Xiang Cheng
Theranostics 2018; 8(16): 4552-4562. doi:10.7150/thno.24723
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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[18F]Fludarabine-PET as a promising tool for differentiating CNS lymphoma and glioblastoma: Comparative analysis with [18F]FDG in human xenograft models
Narinée Hovhannisyan, Fabien Fillesoye, Stéphane Guillouet, Méziane Ibazizene, Jérôme Toutain, Fabienne Gourand, Samuel Valable, Benoit Plancoulaine, Louisa Barré
Theranostics 2018; 8(16): 4563-4573. doi:10.7150/thno.26754
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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Imaging and therapy of ovarian cancer: clinical application of nanoparticles and future perspectives
Giovanni Di Lorenzo, Giuseppe Ricci, Giovanni Maria Severini, Federico Romano, Stefania Biffi
Theranostics 2018; 8(16): 4279-4294. doi:10.7150/thno.26345
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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State-of-the-art of microbubble-assisted blood-brain barrier disruption
Kang-Ho Song, Brandon K. Harvey, Mark A. Borden
Theranostics 2018; 8(16): 4393-4408. doi:10.7150/thno.26869
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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AMPK: Potential Therapeutic Target for Ischemic Stroke
Shuai Jiang, Tian Li, Ting Ji, Wei Yi, Zhi Yang, Simeng Wang, Yang Yang, Chunhu Gu
Theranostics 2018; 8(16): 4535-4551. doi:10.7150/thno.25674
[Abstract] [Full text] [PDF] [PubMed] [PMC]