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Volume 8 (1); 2018

Research Paper

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Acid-degradable Dextran as an Image Guided siRNA Carrier for COX-2 Downregulation
Zhihang Chen, Balaji Krishnamachary, Marie-France Penet, Zaver M. Bhujwalla
Theranostics 2018; 8(1): 1-12. doi:10.7150/thno.21052
[Abstract] [Full text] [PDF]


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Changes in the microarchitecture of the pancreatic cancer stroma are linked to neutrophil-dependent reprogramming of stellate cells and reflected by diffusion-weighted magnetic resonance imaging
Philipp Mayer, Christine Dinkic, Ralf Jesenofsky, Miriam Klauss, Peter Schirmacher, Ulrike Dapunt, Thilo Hackert, Florian Uhle, G. Maria Hänsch, Matthias M. Gaida
Theranostics 2018; 8(1): 13-30. doi:10.7150/thno.21089
[Abstract] [Full text] [PDF]


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A Novel DNA Aptamer for Dual Targeting of Polymorphonuclear Myeloid-derived Suppressor Cells and Tumor Cells
Haoran Liu, Junhua Mai, Jianliang Shen, Joy Wolfram, Zhaoqi Li, Guodong Zhang, Rong Xu, Yan Li, Chaofeng Mu, Youli Zu, Xin Li, Ganesh L. Lokesh, Varatharasa Thiviyanathan, David E. Volk, David G. Gorenstein, Mauro Ferrari, Zhongbo Hu, Haifa Shen
Theranostics 2018; 8(1): 31-44. doi:10.7150/thno.21342
[Abstract] [Full text] [PDF]


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Therapeutic Effects of Targeted PPARɣ Activation on Inflamed High-Risk Plaques Assessed by Serial Optical Imaging In Vivo
Jah Yeon Choi, Jiheun Ryu, Hyun Jung Kim, Joon Woo Song, Joo Hee Jeon, Dae-Hee Lee, Dong Joo Oh, Dae-Gab Gweon, Wang-Yuhl Oh, Hongki Yoo, Kyeongsoon Park, Jin Won Kim
Theranostics 2018; 8(1): 45-60. doi:10.7150/thno.20885
[Abstract] [Full text] [PDF]


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Epigenomic characterization of a p53-regulated 3p22.2 tumor suppressor that inhibits STAT3 phosphorylation via protein docking and is frequently methylated in esophageal and other carcinomas
Lili Li, Juan Xu, Guohua Qiu, Jianming Ying, Zhenfang Du, Tingxiu Xiang, Kai Yau Wong, Gopesh Srivastava, Xiao-Feng Zhu, Tony S Mok, Anthony TC Chan, Francis KL Chan, Richard F Ambinder, Qian Tao
Theranostics 2018; 8(1): 61-77. doi:10.7150/thno.20893
[Abstract] [Full text] [PDF]


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A Mucin1 C-terminal Subunit-directed Monoclonal Antibody Targets Overexpressed Mucin1 in Breast Cancer
Guang Wu, Dongbum Kim, Jung Nam Kim, Sangkyu Park, Sony Maharjan, Heeju Koh, Kyungduk Moon, Younghee Lee, Hyung-Joo Kwon
Theranostics 2018; 8(1): 78-91. doi:10.7150/thno.21278
[Abstract] [Full text] [PDF]


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Tumor-penetrating Peptide Conjugated and Doxorubicin Loaded T1-T2 Dual Mode MRI Contrast Agents Nanoparticles for Tumor Theranostics
Lipeng Gao, Jing Yu, Yang Liu, Jinge Zhou, Lei Sun, Jing Wang, Jianzhong Zhu, Hui Peng, Weiyue Lu, Lei Yu, Zhiqiang Yan, Yiting Wang
Theranostics 2018; 8(1): 92-108. doi:10.7150/thno.21074
[Abstract] [Full text] [PDF]


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PrLZ increases prostate cancer docetaxel resistance by inhibiting LKB1/AMPK-mediated autophagy
Jin Zeng, Wei Liu, Yi-Zeng Fan, Da-Lin He, Lei Li
Theranostics 2018; 8(1): 109-123. doi:10.7150/thno.20356
[Abstract] [Full text] [PDF]


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Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes
Rachel R. Besser, Matthew Ishahak, Vera Mayo, Daniel Carbonero, Isabella Claure, Ashutosh Agarwal
Theranostics 2018; 8(1): 124-140. doi:10.7150/thno.19441
[Abstract] [Full text] [PDF]


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Ultrasound Molecular Imaging of VEGFR-2 in Clear-Cell Renal Cell Carcinoma Tracks Disease Response to Antiangiogenic and Notch-Inhibition Therapy
Juan D. Rojas, Fanglue Lin, Yun-Chen Chiang, Anna Chytil, Diana C. Chong, Victoria L. Bautch, W. Kimryn Rathmell, Paul A. Dayton
Theranostics 2018; 8(1): 141-155. doi:10.7150/thno.19658
[Abstract] [Full text] [PDF]


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Early Assessment of Tumor Response to Radiation Therapy using High-Resolution Quantitative Microvascular Ultrasound Imaging
Sandeep K. Kasoji, Judith N. Rivera, Ryan C. Gessner, Sha X. Chang, Paul A. Dayton
Theranostics 2018; 8(1): 156-168. doi:10.7150/thno.19703
[Abstract] [Full text] [PDF]


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Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function
Yin Hu, Shan-Shan Rao, Zhen-Xing Wang, Jia Cao, Yi-Juan Tan, Juan Luo, Hong-Ming Li, Wei-She Zhang, Chun-Yuan Chen, Hui Xie
Theranostics 2018; 8(1): 169-184. doi:10.7150/thno.21234
[Abstract] [Full text] [PDF]


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RHCG Suppresses Tumorigenicity and Metastasis in Esophageal Squamous Cell Carcinoma via Inhibiting NF-κB Signaling and MMP1 Expression
Xiao-Yan Ming, Xu Zhang, Ting-Ting Cao, Li-Yi Zhang, Jia-Li Qi, Ngar-Woon Kam, Xu-Ming Tang, Yu-Zhu Cui, Bao-Zhu Zhang, Yan Li, Yan-Ru Qin, Xin-Yuan Guan
Theranostics 2018; 8(1): 185-198. doi:10.7150/thno.21383
[Abstract] [Full text] [PDF]


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Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1
Zhengyang Zeng, Runhong Zhang, Wei Hong, Yuting Cheng, Huijuan Wang, Yange Lang, Zhenglin Ji, Yingliang Wu, Wenxin Li, Youli Xie, Zhijian Cao
Theranostics 2018; 8(1): 199-211. doi:10.7150/thno.21425
[Abstract] [Full text] [PDF]


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Glutathione Peroxidase 3 Delivered by hiPSC-MSCs Ameliorated Hepatic IR Injury via Inhibition of Hepatic Senescence
Xiang Qi, Kevin Tak-Pan Ng, Qizhou Lian, Chang Xian Li, Wei Geng, Chang Chun Ling, Wai Ho Yeung, Yuen Yuen Ma, Xiao Bing Liu, Hui Liu, Jiang Liu, Xin Xiang Yang, Chung Mau Lo, Kwan Man
Theranostics 2018; 8(1): 212-222. doi:10.7150/thno.21656
[Abstract] [Full text] [PDF]


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An Albumin-binding Polypeptide Both Targets Cytotoxic T Lymphocyte Vaccines to Lymph Nodes and Boosts Vaccine Presentation by Dendritic Cells
Peng Wang, Peng Zhao, Shuyun Dong, Tiefeng Xu, Xiao He, Mingnan Chen
Theranostics 2018; 8(1): 223-236. doi:10.7150/thno.21691
[Abstract] [Full text] [PDF]


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Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging of Antiretroviral Drug Particle Tissue-Cell Biodistribution
Bhavesh D. Kevadiya, Christopher Woldstad, Brendan M. Ottemann, Prasanta Dash, Balasrinivasa R. Sajja, Benjamin Lamberty, Brenda Morsey, Ted Kocher, Rinku Dutta, Aditya N. Bade, Yutong Liu, Shannon E. Callen, Howard S. Fox, Siddappa N. Byrareddy, JoEllyn M. McMillan, Tatiana K. Bronich, Benson J. Edagwa, Michael D. Boska, Howard E. Gendelman
Theranostics 2018; 8(1): 256-276. doi:10.7150/thno.22764
[Abstract] [Full text] [PDF]


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Tiresias: Context-sensitive Approach to Decipher the Presence and Strength of MicroRNA Regulatory Interactions
Jinkyu Koo, Jinyi Zhang, Somali Chaterji
Theranostics 2018; 8(1): 277-291. doi:10.7150/thno.22065
[Abstract] [Full text] [PDF]


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Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases
Nadia Falzone, Nicole L. Ackerman, Liset de la Fuente Rosales, Mario A. Bernal, Xiaoxuan Liu, Sarah GJA Peeters, Manuel Sarmiento Soto, Aurélien Corroyer-Dulmont, Myriam Bernaudin, Elisa Grimoin, Omar Touzani, Nicola R. Sibson, Katherine A. Vallis
Theranostics 2018; 8(1): 292-303. doi:10.7150/thno.22217
[Abstract] [Full text] [PDF]

Review

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Exosome Theranostics: Biology and Translational Medicine
Chuanjiang He, Shu Zheng, Yan Luo, Ben Wang
Theranostics 2018; 8(1): 237-255. doi:10.7150/thno.21945
[Abstract] [Full text] [PDF]