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Theranostics 2024; 14(1):324-340. doi:10.7150/thno.86759 This issue Cite

Research Paper

In situ theranostic platform combining highly localized magnetic fluid hyperthermia, magnetic particle imaging, and thermometry in 3D

Oliver Buchholz^1✉, Kulthisa Sajjamark², Jochen Franke², Huimin Wei³, André Behrends³, Christian Münkel¹, Cordula Grüttner⁴, Pierre Levan⁵, Dominik von Elverfeldt⁶, Matthias Graeser^3,7, Thorsten Buzug^3,7, Sébastien Bär^1,6†✉, Ulrich G. Hofmann^1†

1. Section for Neuroelectronic Systems, Department of Neurosurgery, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
2. Bruker BioSpin MRI GmbH, Preclinical Imaging Division, Ettlingen, Germany.
3. Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE, Lübeck, Germany.
4. Micromod Partikeltechnologie GmbH, Rostock, Germany.
5. Department of Radiology and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
6. Division of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
7. Institute of Medical Engineering, University of Lübeck, Germany.
^†These authors contributed equally to this work

✉ Corresponding authors: oliver.buchholzde; sebastien.baerde

Abstract

Theranostic platforms, combining diagnostic and therapeutic approaches within one system, have garnered interest in augmenting invasive surgical, chemical, and ionizing interventions. Magnetic particle imaging (MPI) offers a quite recent alternative to established radiation-based diagnostic modalities with its versatile tracer material (superparamagnetic iron oxide nanoparticles, SPION). It also offers a bimodal theranostic framework that can combine tomographic imaging with therapeutic techniques using the very same SPION.

Methods: We show the interleaved combination of MPI-based imaging, therapy (highly localized magnetic fluid hyperthermia (MFH)) and therapy safety control (MPI-based thermometry) within one theranostic platform in all three spatial dimensions using a commercial MPI system and a custom-made heating insert. The heating characteristics as well as theranostic applications of the platform were demonstrated by various phantom experiments using commercial SPION.

Results: We have shown the feasibility of an MPI-MFH-based theranostic platform by demonstrating high spatial control of the therapeutic target, adequate MPI-based thermometry, and successful in situ interleaved MPI-MFH application.

Conclusions: MPI-MFH-based theranostic platforms serve as valuable tools that enable the synergistic integration of diagnostic and therapeutic approaches. The transition into in vivo studies will be essential to further validate their potential, and it holds promising prospects for future advancements.

Keywords: Magnetic Particle Imaging, Magnetic Fluid Hyperthermia, Theranostic, Thermometry, Imaging

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