Theranostics 2023; 13(5):1669-1683. doi:10.7150/thno.81511 This issue Cite

Research Paper

Ultrasound-controlled MXene-based Schottky heterojunction improves anti-infection and osteogenesis properties

Hongchuan Wang1*, Na Mu2*, Yaqi He1*, Xiaoguang Zhang1, Jie Lei1, Cao Yang1✉, Liang Ma1✉, Yong Gao1✉

1. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
2. College of Agronomy, Xinjiang Agriculture University, Urumqi, Xinjiang, China.
* The three authors share co-first authorship because of their equal contributions.

Citation:
Wang H, Mu N, He Y, Zhang X, Lei J, Yang C, Ma L, Gao Y. Ultrasound-controlled MXene-based Schottky heterojunction improves anti-infection and osteogenesis properties. Theranostics 2023; 13(5):1669-1683. doi:10.7150/thno.81511. https://www.thno.org/v13p1669.htm
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Abstract

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Background: The current clinical treatment of osteomyelitis is limited by the emergence of drug-resistant bacteria, which often leads to the failure of traditional antibiotic treatment and large bone defects. Sonodynamic therapy (SDT) is a new strategy that is widely used to overcome the problem of bacterial resistance to antibiotic therapy as well as poor tissue penetration using near-infrared light in photodynamic therapy (PDT). Therefore, it is necessary to develop a new sonosensitizer that can kill bacteria and promote bone repair.

Methods: Herein, we developed a sonosensitizer, porphyrin metal-organic framework (HNTM), with a Schottky junction modified by Ti3C2 nanosheets (HN-Ti3C2) for highly efficient sonodynamic therapy of osteomyelitis and bone regeneration.

Results: Ti3C2 greatly improves the acoustic catalytic performance by rapidly transferring the charge carriers generated by HNTM under ultrasound (US) irradiation, which killing drug-resistant bacteria through the generation of large amounts of reactive oxygen species (ROS). And HN-Ti3C2 shows excellent 99.75% antibacterial effectiveness against MRSA. In addition, HN-Ti3C2 generates a sonocurrent under low-intensity US to promote the repair of bone defects for a long time period. Mechanistic research using CCK-8 and RNA-seq showed that HN-Ti3C2 nanocomposites can promote the proliferation of stem cells by regulating the cell cycle, DNA replication, and apoptosis. In addition, after low-intensity US irradiation, HN-Ti3C2 promotes osteogenic differentiation via some key signaling pathways, including the calcium, Wnt, and TGF-beta signaling pathways, according to the Kyoto Encyclopedia of Genes and Genomes (KEGG). In a MRSA-infected rat tibial osteomyelitis model, HN-Ti3C2 successfully eliminated the infection and significantly improved bone regeneration under US irradiation.

Conclusion: This study indicates that engineered HN-Ti3C2 is a distinctive nanocomposite for successful osteomyelitis treatment.

Keywords: Sonodynamic therapy, Antibacterial therapy, Schottky Heterojunction, Bone regeneration, Reactive oxygen species


Citation styles

APA
Wang, H., Mu, N., He, Y., Zhang, X., Lei, J., Yang, C., Ma, L., Gao, Y. (2023). Ultrasound-controlled MXene-based Schottky heterojunction improves anti-infection and osteogenesis properties. Theranostics, 13(5), 1669-1683. https://doi.org/10.7150/thno.81511.

ACS
Wang, H.; Mu, N.; He, Y.; Zhang, X.; Lei, J.; Yang, C.; Ma, L.; Gao, Y. Ultrasound-controlled MXene-based Schottky heterojunction improves anti-infection and osteogenesis properties. Theranostics 2023, 13 (5), 1669-1683. DOI: 10.7150/thno.81511.

NLM
Wang H, Mu N, He Y, Zhang X, Lei J, Yang C, Ma L, Gao Y. Ultrasound-controlled MXene-based Schottky heterojunction improves anti-infection and osteogenesis properties. Theranostics 2023; 13(5):1669-1683. doi:10.7150/thno.81511. https://www.thno.org/v13p1669.htm

CSE
Wang H, Mu N, He Y, Zhang X, Lei J, Yang C, Ma L, Gao Y. 2023. Ultrasound-controlled MXene-based Schottky heterojunction improves anti-infection and osteogenesis properties. Theranostics. 13(5):1669-1683.

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