ISSN: 1838-7640Theranostics
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Theranostics 2021; 11(10):4839-4857. doi:10.7150/thno.56747 This issue Cite
Review
The double-edged roles of ROS in cancer prevention and therapy
1. Department of Thoracic Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.
2. CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
3. Department of Biochemistry & Molecular Biology, School of Life Sciences, China Medical University, Shenyang, 110122, China.
Citation:
Wang Y, Qi H, Liu Y, Duan C, Liu X, Xia T, Chen D, Piao Hl, Liu HX. The double-edged roles of ROS in cancer prevention and therapy. Theranostics 2021; 11(10):4839-4857. doi:10.7150/thno.56747. https://www.thno.org/v11p4839.htm
Other stylesAbstract
Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative metabolism and are associated with a number of human diseases. The reprogramming of redox metabolism induces abnormal accumulation of ROS in cancer cells. It has been widely accepted that ROS play opposite roles in tumor growth, metastasis and apoptosis according to their different distributions, concentrations and durations in specific subcellular structures. These double-edged roles in cancer progression include the ROS-dependent malignant transformation and the oxidative stress-induced cell death. In this review, we summarize the notable literatures on ROS generation and scavenging, and discuss the related signal transduction networks and corresponding anticancer therapies. There is no doubt that an improved understanding of the sophisticated mechanism of redox biology is imperative to conquer cancer.
Citation styles
APA
Wang, Y., Qi, H., Liu, Y., Duan, C., Liu, X., Xia, T., Chen, D., Piao, H.l., Liu, H.X. (2021). The double-edged roles of ROS in cancer prevention and therapy. Theranostics, 11(10), 4839-4857. https://doi.org/10.7150/thno.56747.
ACS
Wang, Y.; Qi, H.; Liu, Y.; Duan, C.; Liu, X.; Xia, T.; Chen, D.; Piao, H.l.; Liu, H.X. The double-edged roles of ROS in cancer prevention and therapy. Theranostics 2021, 11 (10), 4839-4857. DOI: 10.7150/thno.56747.
NLM
Wang Y, Qi H, Liu Y, Duan C, Liu X, Xia T, Chen D, Piao Hl, Liu HX. The double-edged roles of ROS in cancer prevention and therapy. Theranostics 2021; 11(10):4839-4857. doi:10.7150/thno.56747. https://www.thno.org/v11p4839.htm
CSE
Wang Y, Qi H, Liu Y, Duan C, Liu X, Xia T, Chen D, Piao Hl, Liu HX. 2021. The double-edged roles of ROS in cancer prevention and therapy. Theranostics. 11(10):4839-4857.
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