Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Theranostics 2021; 11(3):1046-1058. doi:10.7150/thno.53326 This issue Cite

Review

The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction

Yu-Yan Xiong*, Zhao-Ting Gong*, Rui-Jie Tang, Yue-Jin Yang✉

State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100037, China
*These authors contributed equally to this work.

✉ Corresponding author: Yue-Jin Yang, MD, PhD. E-mail: yangyuejinorg or yangyjfwcom

Citation:
Xiong YY, Gong ZT, Tang RJ, Yang YJ. The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction. Theranostics 2021; 11(3):1046-1058. doi:10.7150/thno.53326. https://www.thno.org/v11p1046.htm
Other styles

File import instruction

Abstract

Graphic abstract

Acute myocardial infarction (AMI) is one of the leading causes of mortality around the world, and the inflammatory response plays a pivotal role in the progress of myocardial necrosis and ventricular remodeling, dysfunction and heart failure after AMI. Therapies aimed at modulating immune response after AMI on a molecular and cellular basis are urgently needed. Exosomes are a type of extracellular vesicles which contain a large amount of biologically active substances, like lipids, nucleic acids, proteins and so on. Emerging evidence suggests key roles of exosomes in immune regulation post AMI. A variety of immune cells participate in the immunomodulation after AMI, working together to clean up necrotic tissue and repair damaged myocardium. Stem cell therapy for myocardial infarction has long been a research hotspot during the last two decades and exosomes secreted by stem cells are important active substances and have similar therapeutic effects of immunomodulation, anti-apoptosis, anti-fibrotic and angiogenesis to those of stem cells themselves. Therefore, in this review, we focus on the characteristics and roles of exosomes produced by both of endogenous immune cells and exogenous stem cells in myocardial repair through immunomodulation after AMI.

Keywords: Myocardial infarction, exosome, immunomodulation, immune cells, stem cells

Citation styles

APA
Xiong, Y.Y., Gong, Z.T., Tang, R.J., Yang, Y.J. (2021). The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction. Theranostics, 11(3), 1046-1058. https://doi.org/10.7150/thno.53326.

ACS
Xiong, Y.Y.; Gong, Z.T.; Tang, R.J.; Yang, Y.J. The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction. Theranostics 2021, 11 (3), 1046-1058. DOI: 10.7150/thno.53326.

NLM
Xiong YY, Gong ZT, Tang RJ, Yang YJ. The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction. Theranostics 2021; 11(3):1046-1058. doi:10.7150/thno.53326. https://www.thno.org/v11p1046.htm

CSE
Xiong YY, Gong ZT, Tang RJ, Yang YJ. 2021. The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction. Theranostics. 11(3):1046-1058.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use