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Theranostics 2020; 10(16):7273-7286. doi:10.7150/thno.44668 This issue Cite

Research Paper

Complementary autophagy inhibition and glucose metabolism with rattle-structured polydopamine@mesoporous silica nanoparticles for augmented low-temperature photothermal therapy and in vivo photoacoustic imaging

Leihou Shao1,3*, Yunhao Li2*, Feifei Huang4, Xuan Wang1,5, Jianqing Lu1, Fan Jia1,5, Zian Pan1,5, Xinyue Cui1, Guanglu Ge1,5, Xiongwei Deng1✉, Yan Wu1,5✉

1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, P. R. China.
2. Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, P. R. China.
3. Beijing Key Laboratory of Organic Materials Testing Technology and Quality Evaluation, Beijing Center for Physical and Chemical Analysis, Beijing, 100089, China.
4. The Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
5. University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
*These authors contributed equally to this work.

✉ Corresponding authors: E-mails: dengxw2018cn (X. Deng); wuycn (Y. Wu).

Citation:
Shao L, Li Y, Huang F, Wang X, Lu J, Jia F, Pan Z, Cui X, Ge G, Deng X, Wu Y. Complementary autophagy inhibition and glucose metabolism with rattle-structured polydopamine@mesoporous silica nanoparticles for augmented low-temperature photothermal therapy and in vivo photoacoustic imaging. Theranostics 2020; 10(16):7273-7286. doi:10.7150/thno.44668. https://www.thno.org/v10p7273.htm
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Abstract

Graphic abstract

Rattle-structured nanoparticles with movable cores, porous shells and hollow interiors have shown great effectiveness in drug delivery and cancer theranostics. Targeting autophagy and glucose have provided alternative strategies for cancer intervention therapy. Herein, rattle-structured polydopamine@mesoporous silica nanoparticles were prepared for in vivo photoacoustic (PA) imaging and augmented low-temperature photothermal therapy (PTT) via complementary autophagy inhibition and glucose metabolism.

Methods: The multifunctional rattle-structured nanoparticles were designed with the nanocore of PDA and the nanoshell of hollow mesoporous silica (PDA@hm) via a four-step process. PDA@hm was then loaded with autophagy inhibitor chloroquine (CQ) and conjugated with glucose consumer glucose oxidase (GOx) (PDA@hm@CQ@GOx), forming a corona-like structure nanoparticle.

Results: The CQ and GOx were loaded into the cavity and decorated onto the surface of PDA@hm, respectively. The GOx-mediated tumor starvation strategy would directly suppress the expression of HSP70 and HSP90, resulting in an enhanced low-temperature PTT induced by PDA nanocore. In addition, autophagy inhibition by the released CQ made up for the loss of low-temperature PTT and starvation efficiencies by PTT- and starvation-activated autophagy, realizing augmented therapy efficacy. Furthermore, the PDA nanocore in the PDA@hm@CQ@GOx could be also used for PA imaging.

Conclusion: Such a “drugs” loaded rattle-structured nanoparticle could be used for augmented low-temperature PTT through complementarily regulating glucose metabolism and inhibiting autophagy and in vivo photoacoustic imaging.

Keywords: autophagy inhibition, rattle structure, polydopamine, glucose oxidase, low-temperature PTT

Citation styles

APA
Shao, L., Li, Y., Huang, F., Wang, X., Lu, J., Jia, F., Pan, Z., Cui, X., Ge, G., Deng, X., Wu, Y. (2020). Complementary autophagy inhibition and glucose metabolism with rattle-structured polydopamine@mesoporous silica nanoparticles for augmented low-temperature photothermal therapy and in vivo photoacoustic imaging. Theranostics, 10(16), 7273-7286. https://doi.org/10.7150/thno.44668.

ACS
Shao, L.; Li, Y.; Huang, F.; Wang, X.; Lu, J.; Jia, F.; Pan, Z.; Cui, X.; Ge, G.; Deng, X.; Wu, Y. Complementary autophagy inhibition and glucose metabolism with rattle-structured polydopamine@mesoporous silica nanoparticles for augmented low-temperature photothermal therapy and in vivo photoacoustic imaging. Theranostics 2020, 10 (16), 7273-7286. DOI: 10.7150/thno.44668.

NLM
Shao L, Li Y, Huang F, Wang X, Lu J, Jia F, Pan Z, Cui X, Ge G, Deng X, Wu Y. Complementary autophagy inhibition and glucose metabolism with rattle-structured polydopamine@mesoporous silica nanoparticles for augmented low-temperature photothermal therapy and in vivo photoacoustic imaging. Theranostics 2020; 10(16):7273-7286. doi:10.7150/thno.44668. https://www.thno.org/v10p7273.htm

CSE
Shao L, Li Y, Huang F, Wang X, Lu J, Jia F, Pan Z, Cui X, Ge G, Deng X, Wu Y. 2020. Complementary autophagy inhibition and glucose metabolism with rattle-structured polydopamine@mesoporous silica nanoparticles for augmented low-temperature photothermal therapy and in vivo photoacoustic imaging. Theranostics. 10(16):7273-7286.

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