Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Theranostics 2020; 10(13):5979-5997. doi:10.7150/thno.40122 This issue Cite

Review

Mesenchymal stromal/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities

Suzy Varderidou-Minasian1,2, Magdalena J. Lorenowicz1,2✉

1. Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
2. Regenerative Medicine Center, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands

✉ Corresponding author: Magdalena Lorenowicz, PhD, Address: Regenerative Medicine Center, UMC Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands. Tel: +31- 88-755-67941; Email: m.j.lorenowicznl

Citation:
Varderidou-Minasian S, Lorenowicz MJ. Mesenchymal stromal/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities. Theranostics 2020; 10(13):5979-5997. doi:10.7150/thno.40122. https://www.thno.org/v10p5979.htm
Other styles

File import instruction

Abstract

Graphic abstract

Mesenchymal stem/stromal cells (MSCs) are important players in tissue homeostasis and regeneration owing to their immunomodulatory potential and release of trophic factors that promote healing. They have been increasingly used in clinical trials to treat multiple conditions associated with inflammation and tissue damage such as graft versus host disease, orthopedic injuries and cardiac and liver diseases. Recent evidence demonstrates that their beneficial effects are derived, at least in part, from their secretome. In particular, data from animal models and first-in-man studies indicate that MSC-derived extracellular vesicles (MSC-EVs) can exert similar therapeutic potential as their cells of origin. MSC-EVs are membranous structures loaded with proteins, lipids, carbohydrates and nucleic acids, which play an important role in cell-cell communication and may represent an attractive alternative for cell-based therapy. In this article we summarize recent advances in the use of MSC-EVs for tissue repair. We highlight several isolation and characterization approaches used to enrich MSC-derived EVs. We discuss our current understanding of the relative contribution of the MSC-EVs to the immunomodulatory and regenerative effects mediated by MSCs and MSC secretome. Finally we highlight the challenges and opportunities, which come with the potential use of MSC-EVs as cell free therapy for conditions that require tissue repair.

Keywords: mesenchymal stromal/stem cells, extracellular vesicles, isolation, in vivo, tissue repair

Citation styles

APA
Varderidou-Minasian, S., Lorenowicz, M.J. (2020). Mesenchymal stromal/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities. Theranostics, 10(13), 5979-5997. https://doi.org/10.7150/thno.40122.

ACS
Varderidou-Minasian, S.; Lorenowicz, M.J. Mesenchymal stromal/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities. Theranostics 2020, 10 (13), 5979-5997. DOI: 10.7150/thno.40122.

NLM
Varderidou-Minasian S, Lorenowicz MJ. Mesenchymal stromal/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities. Theranostics 2020; 10(13):5979-5997. doi:10.7150/thno.40122. https://www.thno.org/v10p5979.htm

CSE
Varderidou-Minasian S, Lorenowicz MJ. 2020. Mesenchymal stromal/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities. Theranostics. 10(13):5979-5997.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use