Full Text | PDF

Share on facebook Share on tweeters Share on linkedin Share on googleplus

Theranostics 2020; 10(9):4150-4167. doi:10.7150/thno.42735 This issue Cite

Review

F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects

Dinesh Singh Tekcham2*, Di Chen2*, Yu Liu1,2, Ting Ling2, Yi Zhang1,2, Huan Chen2, Wen Wang2, Wuxiyar Otkur2, Huan Qi2, Tian Xia2, Xiaolong Liu2, Hai-long Piao2✉, Hongxu Liu1✉

1. Department of Thoracic Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.
2. CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
* Equal contribution

✉ Corresponding authors: Hai-long Piao, hpiaoac.cn; Hongxu Liu, hxliuedu.cn

Citation:
Tekcham DS, Chen D, Liu Y, Ling T, Zhang Y, Chen H, Wang W, Otkur W, Qi H, Xia T, Liu X, Piao Hl, Liu H. F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects. Theranostics 2020; 10(9):4150-4167. doi:10.7150/thno.42735. https://www.thno.org/v10p4150.htm
Other styles

File import instruction

Abstract

Graphic abstract

E3 ubiquitin ligases play a critical role in cellular mechanisms and cancer progression. F-box protein is the core component of the SKP1-cullin 1-F-box (SCF)-type E3 ubiquitin ligase and directly binds to substrates by various specific domains. According to the specific domains, F-box proteins are further classified into three sub-families: 1) F-box with leucine rich amino acid repeats (FBXL); 2) F-box with WD 40 amino acid repeats (FBXW); 3) F-box only with uncharacterized domains (FBXO). Here, we summarize the substrates of F-box proteins, discuss the important molecular mechanism and emerging role of F-box proteins especially from the perspective of cancer development and progression. These findings will shed new light on malignant tumor progression mechanisms, and suggest the potential role of F-box proteins as cancer biomarkers and therapeutic targets for future cancer treatment.

Keywords: F-box, E3 ligase, ubiquitin, substrate, cancer progression

Citation styles

APA
Tekcham, D.S., Chen, D., Liu, Y., Ling, T., Zhang, Y., Chen, H., Wang, W., Otkur, W., Qi, H., Xia, T., Liu, X., Piao, H.l., Liu, H. (2020). F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects. Theranostics, 10(9), 4150-4167. https://doi.org/10.7150/thno.42735.

ACS
Tekcham, D.S.; Chen, D.; Liu, Y.; Ling, T.; Zhang, Y.; Chen, H.; Wang, W.; Otkur, W.; Qi, H.; Xia, T.; Liu, X.; Piao, H.l.; Liu, H. F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects. Theranostics 2020, 10 (9), 4150-4167. DOI: 10.7150/thno.42735.

NLM
Tekcham DS, Chen D, Liu Y, Ling T, Zhang Y, Chen H, Wang W, Otkur W, Qi H, Xia T, Liu X, Piao Hl, Liu H. F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects. Theranostics 2020; 10(9):4150-4167. doi:10.7150/thno.42735. https://www.thno.org/v10p4150.htm

CSE
Tekcham DS, Chen D, Liu Y, Ling T, Zhang Y, Chen H, Wang W, Otkur W, Qi H, Xia T, Liu X, Piao Hl, Liu H. 2020. F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects. Theranostics. 10(9):4150-4167.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use