Theranostics 2020; 10(7):3190-3205. doi:10.7150/thno.42640 This issue Cite

Review

RNA-based scaffolds for bone regeneration: application and mechanisms of mRNA, miRNA and siRNA

Qiuping Leng1,2, Lini Chen1,2, Yonggang Lv1,2✉

1. Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, P. R. China
2. Mechanobiology and Regenerative Medicine Laboratory, Bioengineering College, Chongqing University, Chongqing 400044, P. R. China

Citation:
Leng Q, Chen L, Lv Y. RNA-based scaffolds for bone regeneration: application and mechanisms of mRNA, miRNA and siRNA. Theranostics 2020; 10(7):3190-3205. doi:10.7150/thno.42640. https://www.thno.org/v10p3190.htm
Other styles

File import instruction

Abstract

Graphic abstract

Globally, more than 1.5 million patients undergo bone graft surgeries annually, and the development of biomaterial scaffolds that mimic natural bone for bone grafting remains a tremendous challenge. In recent decades, due to the improved understanding of the mechanisms of bone remodeling and the rapid development of gene therapy, RNA (including messenger RNA (mRNA), microRNA (miRNA), and short interfering RNA (siRNA)) has attracted increased attention as a new tool for bone tissue engineering due to its unique nature and great potential to cure bone defects. Different types of RNA play roles via a variety of mechanisms in bone-related cells in vivo as well as after synthesis in vitro. In addition, RNAs are delivered to injured sites by loading into scaffolds or systemic administration after combination with vectors for bone tissue engineering. However, the challenge of effectively and stably delivering RNA into local tissue remains to be solved. This review describes the mechanisms of the three types of RNAs and the application of the relevant types of RNA delivery vectors and scaffolds in bone regeneration. The improvements in their development are also discussed.

Keywords: RNA-based therapy, mRNA, siRNA, miRNA, scaffold, nonviral vector, bone regeneration, delivery


Citation styles

APA
Leng, Q., Chen, L., Lv, Y. (2020). RNA-based scaffolds for bone regeneration: application and mechanisms of mRNA, miRNA and siRNA. Theranostics, 10(7), 3190-3205. https://doi.org/10.7150/thno.42640.

ACS
Leng, Q.; Chen, L.; Lv, Y. RNA-based scaffolds for bone regeneration: application and mechanisms of mRNA, miRNA and siRNA. Theranostics 2020, 10 (7), 3190-3205. DOI: 10.7150/thno.42640.

NLM
Leng Q, Chen L, Lv Y. RNA-based scaffolds for bone regeneration: application and mechanisms of mRNA, miRNA and siRNA. Theranostics 2020; 10(7):3190-3205. doi:10.7150/thno.42640. https://www.thno.org/v10p3190.htm

CSE
Leng Q, Chen L, Lv Y. 2020. RNA-based scaffolds for bone regeneration: application and mechanisms of mRNA, miRNA and siRNA. Theranostics. 10(7):3190-3205.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image