ISSN: 1838-7640Theranostics
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Theranostics 2020; 10(25):11656-11672. doi:10.7150/thno.51287 This issue Cite
Research Paper
Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by regioselective overgrowth for in vivo photothermal tumor ablation in the second near-infrared biowindow
School of Materials Science and Engineering, Central South University, Changsha, Hunan 410083, China.
Citation:
Shan B, Wang H, Li L, Zhou G, Wen Y, Chen M, Li M. Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by regioselective overgrowth for in vivo photothermal tumor ablation in the second near-infrared biowindow. Theranostics 2020; 10(25):11656-11672. doi:10.7150/thno.51287. https://www.thno.org/v10p11656.htm
Other stylesAbstract
NIR-II plasmonic materials offer multiple functionalities for in vivo biomedical applications, such as photothermal tumor ablation, surface-enhanced Raman scattering biosensing, photoacoustic imaging, and drug carriers. However, integration of noble metals and plasmonic semiconductors is greatly challenging because of the large lattice-mismatch. This study reports the regioselective overgrowth of Cu2-xSe on gold nanorods (GNRs) for preparation of dual-plasmonic GNR@Cu2-xSe hybrid heterostructures with tunable NIR-II plasmon resonance absorption for in vivo photothermal tumor ablation.
Methods: The regioselective deposition of amorphous Se and its subsequent conversion into Cu2-xSe on the GNRs are performed by altering capping agents to produce the GNR@Cu2-xSe heterostructures of various morphologies. Their photothermal performances for NIR-II photothermal tumor ablation are evaluated both in vitro and in vivo.
Results: We find that the lateral one- and two-side deposition, conformal core-shell coating and island growth of Cu2-xSe on the GNRs can be achieved using different capping agents. The Cu2-xSe domain size in these hybrids can be effectively adjusted by the SeO2 concentration, thereby tuning the NIR-II plasmon bands. A photothermal conversion efficiency up to 58-85% and superior photostability of these dual-plasmonic hybrids can be achieved under the NIR-II laser. Results also show that the photothermal conversion efficiency is dependent on the proportion of optical absorption converted into heat; however, the temperature rise is tightly related to the concentration of their constituents. The excellent NIR-II photothermal effect is further verified in the following in vitro and in vivo experiments.
Conclusions: This study achieves one-side or two-side deposition, conformal core-shell coating, and island deposition of Cu2-xSe on GNRs for GNR@Cu2-xSe heterostructures with NIR-II plasmonic absorption, and further demonstrates their excellent NIR-II photothermal tumor ablation in vivo. This study provides a promising strategy for the rational design of NIR-II dual-plasmonic heterostructures and highlights their therapeutic in vivo potential.
Keywords: plasmonic materials, in vivo photothermal therapy, NIR-II light, site-selective deposition, metal-semiconductor heterostructures
Citation styles
APA
Shan, B., Wang, H., Li, L., Zhou, G., Wen, Y., Chen, M., Li, M. (2020). Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by regioselective overgrowth for in vivo photothermal tumor ablation in the second near-infrared biowindow. Theranostics, 10(25), 11656-11672. https://doi.org/10.7150/thno.51287.
ACS
Shan, B.; Wang, H.; Li, L.; Zhou, G.; Wen, Y.; Chen, M.; Li, M. Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by regioselective overgrowth for in vivo photothermal tumor ablation in the second near-infrared biowindow. Theranostics 2020, 10 (25), 11656-11672. DOI: 10.7150/thno.51287.
NLM
Shan B, Wang H, Li L, Zhou G, Wen Y, Chen M, Li M. Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by regioselective overgrowth for in vivo photothermal tumor ablation in the second near-infrared biowindow. Theranostics 2020; 10(25):11656-11672. doi:10.7150/thno.51287. https://www.thno.org/v10p11656.htm
CSE
Shan B, Wang H, Li L, Zhou G, Wen Y, Chen M, Li M. 2020. Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by regioselective overgrowth for in vivo photothermal tumor ablation in the second near-infrared biowindow. Theranostics. 10(25):11656-11672.
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