Theranostics
2020; 10(25):11462-11478.
doi:10.7150/thno.49778 This issueCite
Review
Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies
Jia-Wei He, Xu-Jie Zhou✉, Ji-Cheng Lv, Hong Zhang
Renal Division, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, 100034, People's Republic of China.
✉ Corresponding author: Dr. Xu-Jie Zhou, MD & Ph.D. E-mail: zhouxujieedu.cn; Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, People's Republic of China. No. 8, Xishiku Street, Xicheng District, Beijing 100034, P.R China. Tel.: +86 10 83572388; Fax: +86 10 66551055.More
Citation:
He JW, Zhou XJ, Lv JC, Zhang H. Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies. Theranostics 2020; 10(25):11462-11478. doi:10.7150/thno.49778. https://www.thno.org/v10p11462.htm
Infections have been considered to play a critical role in the pathogenesis of IgA nephropathy (IgAN) because synpharyngitic hematuria is a common feature in IgAN. However, how infections participate in this process is still debated. More recent studies have also revealed that the alteration of the gut microbiome exerts a profound effect on host immune responses, contributing to the etiology or progression of autoimmunity. Considering IgA as the first line of defense against bacterial and viral antigens, this review evaluates the relationships among intestinal infections, gut microbiome, and IgA for a better understanding of the pathogenesis of IgAN. Moreover, as a prototype of IgA immunity, we provide detailed clarification of IgAN pathogenesis to shed light on other diseases in which IgA plays a role. Finally, we discuss potential therapies focusing on microbes and mucosal immune responses in IgAN.
Keywords: IgA nephropathy, mucosal immune response, infection, gut microbiome, therapy
Citation styles
APA
He, J.W., Zhou, X.J., Lv, J.C., Zhang, H. (2020). Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies. Theranostics, 10(25), 11462-11478. https://doi.org/10.7150/thno.49778.
ACS
He, J.W.; Zhou, X.J.; Lv, J.C.; Zhang, H. Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies. Theranostics 2020, 10 (25), 11462-11478. DOI: 10.7150/thno.49778.
NLM
He JW, Zhou XJ, Lv JC, Zhang H. Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies. Theranostics 2020; 10(25):11462-11478. doi:10.7150/thno.49778. https://www.thno.org/v10p11462.htm
CSE
He JW, Zhou XJ, Lv JC, Zhang H. 2020. Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies. Theranostics. 10(25):11462-11478.
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