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Theranostics 2020; 10(24):11278-11301. doi:10.7150/thno.47289 This issue Cite

Review

Targeting gut microbiota for precision medicine: Focusing on the efficacy and toxicity of drugs

Wuwen Feng1,2, Juan Liu2, Hui Ao2, Shijun Yue3, Cheng Peng1,2✉

1. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
2. State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
3. Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an, China.

✉ Corresponding author: Prof. Cheng Peng, E-mail: pengchengcxycom.

Citation:
Feng W, Liu J, Ao H, Yue S, Peng C. Targeting gut microbiota for precision medicine: Focusing on the efficacy and toxicity of drugs. Theranostics 2020; 10(24):11278-11301. doi:10.7150/thno.47289. https://www.thno.org/v10p11278.htm
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Abstract

Graphic abstract

Intra- and interindividual variation in drug responses is one major reason for the failure of drug therapy, drug toxicity, and even the death of patients. Precision medicine, or personalized medicine, is a field of medicine that customizes an individual's medical diagnosis and treatment based on his/her genes, microbiomes, environments, etc. Over the past decade, a large number of studies have demonstrated that gut microbiota can modify the efficacy and toxicity of drugs, and the extent of the modification varies greatly from person to person because of the variability of the gut microbiota. Personalized manipulation of gut microbiota is an important approach to rectify the abnormal drug response. In this review, we aim to improve drug efficacy and reduce drug toxicity by combining precision medicine and gut microbiota. After describing the interactions between gut microbiota and xenobiotics, we discuss (1) the effects of gut microbiota on drug efficacy and toxicity and the corresponding mechanisms, (2) the variability of gut microbiota, which leads to variation in drug responses, (3) the biomarkers used for the patient stratification and treatment decisions before the use of drugs, and (4) the methods used for the personalized manipulation of gut microbiota to improve drug outcomes. Overall, we hope to improve the drug response by incorporating the knowledge of gut microbiota into clinical practice.

Keywords: gut microbiota, precision medicine, drug toxicity, drug efficacy, gut bacteria engineering

Citation styles

APA
Feng, W., Liu, J., Ao, H., Yue, S., Peng, C. (2020). Targeting gut microbiota for precision medicine: Focusing on the efficacy and toxicity of drugs. Theranostics, 10(24), 11278-11301. https://doi.org/10.7150/thno.47289.

ACS
Feng, W.; Liu, J.; Ao, H.; Yue, S.; Peng, C. Targeting gut microbiota for precision medicine: Focusing on the efficacy and toxicity of drugs. Theranostics 2020, 10 (24), 11278-11301. DOI: 10.7150/thno.47289.

NLM
Feng W, Liu J, Ao H, Yue S, Peng C. Targeting gut microbiota for precision medicine: Focusing on the efficacy and toxicity of drugs. Theranostics 2020; 10(24):11278-11301. doi:10.7150/thno.47289. https://www.thno.org/v10p11278.htm

CSE
Feng W, Liu J, Ao H, Yue S, Peng C. 2020. Targeting gut microbiota for precision medicine: Focusing on the efficacy and toxicity of drugs. Theranostics. 10(24):11278-11301.

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