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Theranostics 2020; 10(22):10057-10074. doi:10.7150/thno.45990 This issue Cite

Research Paper

Palladium-based nanomaterials for cancer imaging and therapy

Yongchun Liu^1#, Jingchao Li^2#, Mei Chen^1✉, Xiaolan Chen², Nanfeng Zheng^2✉

1. College of Materials Science and Engineering, Hunan University, Changsha, China.
2. Department of Chemistry, Xiamen University, Xiamen, China.
#These authors contributed equally to this work.

✉ Corresponding authors: chenmeiedu.cn; nfzhengedu.cn.

Abstract

In recent decade, palladium-based (Pd-based) nanomaterials have shown significant potential for biomedical applications because of their unique optical properties, excellent biocompatibility and high stability in physiological environment. Compared with other intensively studied noble nanomaterials, such as gold (Au) and silver (Ag) nanomaterials, research on Pd-based nanomaterials started late, but the distinctive features, such as high photothermal conversion efficiency and high photothermal stability, have made them getting great attention in the field of nanomedicine. The goal of this review is to provide a comprehensive and critical perspective on the recent progress of Pd-based nanomaterials as imaging contrast agents and therapeutic agents. The imaging section focuses on applications in photoacoustic (PA) imaging, single-photon emission computed tomography (SPECT) imaging, computed tomography (CT) imaging and magnetic resonance (MR) imaging. For treatment of cancer, single photothermal therapy (PTT) and PTT combined with other therapeutic modalities will be discussed. Finally, the safety concerns, forthcoming challenges and perspective of Pd-based nanomaterials on biomedical applications will be presented.

Keywords: Palladium-based nanomaterials, cancer imaging, photothermal therapy, combined cancer therapy, safety profile

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