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Theranostics 2018; 8(22):6322-6349. doi:10.7150/thno.27828 This issue Cite

Review

Dendrimer- and copolymer-based nanoparticles for magnetic resonance cancer theranostics

Sayoni Ray^1*, Zhao Li^1*, Chao-Hsiung Hsu^1,2*, Lian-Pin Hwang², Ying-Chih Lin², Pi-Tai Chou², Yung-Ya Lin^1✉

1. Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA
2. Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan
* These authors contributed equally to this work.

✉ Corresponding author: Yung-Ya Lin, Email- yylinucla.edu, Tel- (310) 206-2856

Abstract

Cancer theranostics is one of the most important approaches for detecting and treating patients at an early stage. To develop such a technique, accurate detection, specific targeting, and controlled delivery are the key components. Various kinds of nanoparticles have been proposed and demonstrated as potential nanovehicles for cancer theranostics. Among them, polymer-like dendrimers and copolymer-based core-shell nanoparticles could potentially be the best possible choices. At present, magnetic resonance imaging (MRI) is widely used for clinical purposes and is generally considered the most convenient and noninvasive imaging modality. Superparamagnetic iron oxide (SPIO) and gadolinium (Gd)-based dendrimers are the major nanostructures that are currently being investigated as nanovehicles for cancer theranostics using MRI. These structures are capable of specific targeting of tumors as well as controlled drug or gene delivery to tumor sites using pH, temperature, or alternating magnetic field (AMF)-controlled mechanisms. Recently, Gd-based pseudo-porous polymer-dendrimer supramolecular nanoparticles have shown 4-fold higher T₁ relaxivity along with highly efficient AMF-guided drug release properties. Core-shell copolymer-based nanovehicles are an equally attractive alternative for designing contrast agents and for delivering anti-cancer drugs. Various copolymer materials could be used as core and shell components to provide biostability, modifiable surface properties, and even adjustable imaging contrast enhancement. Recent advances and challenges in MRI cancer theranostics using dendrimer- and copolymer-based nanovehicles have been summarized in this review article, along with new unpublished research results from our laboratories.

Keywords: dendrimer nanoparticle, copolymer nanoparticle, magnetic resonance, cancer theranostics

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