Theranostics 2017; 7(13):3276-3292. doi:10.7150/thno.19987 This issue
1. Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China;
2. Department of Pharmacy, Sanmenxia Central Hospital, Sanmenxia 472000, China;
3. China Three Gorges University, Yichang 443002, China;
4. National Engineering Research Center for Nanomedicine;
5. Hubei Engineering Research Center for Novel Drug Delivery System, Huazhong University of Science and Technology, Wuhan 430030, China.
There is accumulating evidence that regulating tumor microenvironment plays a vital role in improving antitumor efficiency. Herein, to remodel tumor immune microenvironment and elicit synergistic antitumor effects, lipid-coated biodegradable hollow mesoporous silica nanoparticle (dHMLB) was constructed with co-encapsulation of all-trans retinoic acid (ATRA), doxorubicin (DOX) and interleukin-2 (IL-2) for chemo-immunotherapy. The nanoparticle-mediated combinational therapy provided a benign regulation on tumor microenvironment through activation of tumor infiltrating T lymphocytes and natural killer cells, promotion of cytokines secretion of IFN-γ and IL-12, and down-regulation of immunosuppressive myeloid-derived suppressor cells, cytokine IL-10 and TGF-β. ATRA/DOX/IL-2 co-loaded dHMLB demonstrated significant tumor growth and metastasis inhibition, and also exhibited favorable biodegradability and safety. This nanoplatform has great potential in developing a feasible strategy to remodel tumor immune microenvironment and achieve enhanced antitumor effect.
Keywords: nanoparticles, tumor microenvironment, immunosuppression, drug delivery, cancer treatment.