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Theranostics 2017; 7(2):466-481. doi:10.7150/thno.17411 This issue Cite

Research Paper

Hyaluronic Acid Conjugated Magnetic Prussian Blue@Quantum Dot Nanoparticles for Cancer Theranostics

Yongbo Yang¹, Lijia Jing¹, Xiaoda Li¹, Li Lin¹, Xiuli Yue^2✉, Zhifei Dai^3✉

1. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China;
2. School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150080, China;
3. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.

✉ Corresponding authors: Xiuli Yue, Email: xiulidxcom, Zhifei Dai, Email: zhifei.daiedu.cn.

Abstract

A multifunctional nanotheranostic agent was developed by conjugating both hyaluronic acid and bovine serum albumin coated CuInS₂-ZnS quantum dots onto the surface of magnetic Prussian blue nanoparticles. The obtained nanoagent could serve as an efficient contrast agent to simultaneously enhance near infrared (NIR) fluorescence and magnetic resonance (MR) imaging greatly. The coexistence of magnetic core and CD44 ligand hyaluronic acid was found to largely improve the specific uptake of the nanoagent by CD44 overexpressed HeLa cells upon applying an external magnetic field. Both NIR fluorescence and MR imaging in vivo proved high accumulation of the nanoagent at tumor site due to its excellent CD44 receptor/magnetic dual targeting capability. After intravenous injection of the nanoagent and treatment of external magnetic field, the tumor in nude mice was efficiently ablated upon NIR laser irradiation and the tumor growth inhibition was more than 89.95%. Such nanotheranostic agent is of crucial importance for accurately identifying the size and location of the tumor before therapy, monitoring the photothermal treatment procedure in real-time during therapy, assessing the effectiveness after therapy.

Keywords: Photothermal therapy, Bimodal Imaging, Prussian blue nanoparticles, Fe₃O₄ nanoparticles, Quantum Dots, Tumor targeting.

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