Theranostics 2017; 7(2):319-328. doi:10.7150/thno.18078 This issue Cite

Research Paper

Improved Tumor Uptake by Optimizing Liposome Based RES Blockade Strategy

Xiaolian Sun1,2, Xuefeng Yan2, Orit Jacobson2, Wenjing Sun1, Zhantong Wang1,2, Xiao Tong2, Yuqiong Xia2, Daishun Ling3, Xiaoyuan Chen2✉

1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
2. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, Maryland 20892, United States.
3. Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.

Citation:
Sun X, Yan X, Jacobson O, Sun W, Wang Z, Tong X, Xia Y, Ling D, Chen X. Improved Tumor Uptake by Optimizing Liposome Based RES Blockade Strategy. Theranostics 2017; 7(2):319-328. doi:10.7150/thno.18078. https://www.thno.org/v07p0319.htm
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Abstract

Graphic abstract

Minimizing the sequestration of nanomaterials (NMs) by the reticuloendothelial system (RES) can enhance the circulation time of NMs, and thus increase their tumor-specific accumulation. Liposomes are generally regarded as safe (GRAS) agents that can block the RES reversibly and temporarily. With the help of positron emission tomography (PET), we monitored the in vivo tissue distribution of 64Cu-labeled 40 × 10 nm gold nanorods (Au NRs) after pretreatment with liposomes. We systematically studied the effectiveness of liposome administration by comparing (1) differently charged liposomes; (2) different liposome doses; and (3) varying time intervals between liposome dose and NR dose. By pre-injecting 400 μmol/kg positively charged liposomes into mice 5 h before the Au NRs, the liver and spleen uptakes of Au NRs decreased by 30% and 53%, respectively. Significantly, U87MG tumor uptake of Au NRs increased from 11.5 ± 1.1 %ID/g to 16.1 ± 1.3 %ID/g at 27 h post-injection. Quantitative PET imaging is a valuable tool to understand the fate of NMs in vivo and cationic liposomal pretreatment is a viable approach to reduce RES clearance, prolong circulation, and improve tumor uptake.

Keywords: Reticuloendothelial system, Nanoparticle, Liposome blockade, Positron Emission Tomography, Enhanced tumor uptake.


Citation styles

APA
Sun, X., Yan, X., Jacobson, O., Sun, W., Wang, Z., Tong, X., Xia, Y., Ling, D., Chen, X. (2017). Improved Tumor Uptake by Optimizing Liposome Based RES Blockade Strategy. Theranostics, 7(2), 319-328. https://doi.org/10.7150/thno.18078.

ACS
Sun, X.; Yan, X.; Jacobson, O.; Sun, W.; Wang, Z.; Tong, X.; Xia, Y.; Ling, D.; Chen, X. Improved Tumor Uptake by Optimizing Liposome Based RES Blockade Strategy. Theranostics 2017, 7 (2), 319-328. DOI: 10.7150/thno.18078.

NLM
Sun X, Yan X, Jacobson O, Sun W, Wang Z, Tong X, Xia Y, Ling D, Chen X. Improved Tumor Uptake by Optimizing Liposome Based RES Blockade Strategy. Theranostics 2017; 7(2):319-328. doi:10.7150/thno.18078. https://www.thno.org/v07p0319.htm

CSE
Sun X, Yan X, Jacobson O, Sun W, Wang Z, Tong X, Xia Y, Ling D, Chen X. 2017. Improved Tumor Uptake by Optimizing Liposome Based RES Blockade Strategy. Theranostics. 7(2):319-328.

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