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Theranostics 2015; 5(9):931-945. doi:10.7150/thno.11802 This issue Cite

Research Paper

Smart MoS₂/Fe₃O₄ Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging

Jie Yu^1,2,#, Wenyan Yin^2,#,✉, Xiaopeng Zheng², Gan Tian², Xiao Zhang², Tao Bao², Xinghua Dong², Zhongliang Wang³, Zhanjun Gu^{2, ✉}, Xiaoyan Ma^1,✉, Yuliang Zhao^2,✉

1. Key Laboratory of Polymer Science and Technology, School of Science, Northwestern Polytechnical University, Xi'an, Shaanxi, China
2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Beijing, China
3. School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China
^#Jie Yu and Wenyan Yin contributed equally to this study.

✉ Corresponding authors: Wenyan Yin, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Beijing, China. E-mail: yinwyac.cn or Zhanjun Gu, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Beijing, China. E-mail: zjguac.cn or Xiaoyan Ma, Key Laboratory of Polymer Science and Technology, School of Science, Northwestern Polytechnical University, Xi'an, Shaanxi, China. E-mail: m_xiao_yanaedu.cn or Yuliang Zhao, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Beijing, China. E-mail: zhaoyuliangac.cn More

Abstract

The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS₂ (MS) flakes and Fe₃O₄ (IO) nanoparticles (NPs), where MoS₂ converted near-infrared (NIR) light into heat and Fe₃O₄ NPs served as target moiety directed by external magnetic field to tumor site. The MoS₂/Fe₃O₄ composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method. And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo. Specifically, the MSIOs can be applied as a dual-modal probe for T₂-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption. Furthermore, we demonstrate an effective result for magnetically targeted photothermal ablation of cancer. All these results show a great potential for localized photothermal ablation of cancer spatially/timely guided by the magnetic field and indicated the promise of the multifunctional MSIOs for applications in cancer theranostics.

Keywords: Magnetic target, Photothermal therapy, Magnetic resonance imaging, Photoacoustic tomography imaging, Theranostic.

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