Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Theranostics 2015; 5(2):124-133. doi:10.7150/thno.10014 This issue Cite

Research Paper

ανβ3-targeted Copper Nanoparticles Incorporating an Sn 2 Lipase-Labile Fumagillin Prodrug for Photoacoustic Neovascular Imaging and Treatment

Ruiying Zhang1*, Dipanjan Pan2,3*, Xin Cai1, Xiaoxia Yang2, Angana Senpan2, John S. Allen2, Gregory M. Lanza1, 2✉, Lihong V. Wang1✉

1. Department of Biomedical Engineering, Washington University, St Louis, MO 63130;
2. Department of Medicine, Washington University School of Medicine, St Louis, MO 63108;
3. Current address: Department of Bioengineering and Beckman Institute, University of Illinois, Urbana, IL 61801.
*Authors: equal contribution.

✉ Corresponding authors: Lihong V. Wang, PhD. Department of Biomedical Engineering, Washington University, Whitaker Hall, Room 190D, Campus Box 1097, 1 Brookings Drive, St. Louis, MO 63130. Tel: (314) 935-6152. lhwangedu And Gregory M. Lanza, M More

Citation:
Zhang R, Pan D, Cai X, Yang X, Senpan A, Allen JS, Lanza GM, Wang LV. ανβ3-targeted Copper Nanoparticles Incorporating an Sn 2 Lipase-Labile Fumagillin Prodrug for Photoacoustic Neovascular Imaging and Treatment. Theranostics 2015; 5(2):124-133. doi:10.7150/thno.10014. https://www.thno.org/v05p0124.htm
Other styles

File import instruction

Abstract

Graphic abstract

Photoacoustic (PA) tomography enables multiscale, multicontrast and high-resolution imaging of biological structures. In particular, contrast-enhanced PA imaging offers high-sensitivity noninvasive imaging of neovessel sprout formation and nascent tubules, which are important biomarkers of malignant tumors and progressive atherosclerotic disease. While gold nanoparticles or nanorods have been used as PA contrast agents, we utilized high-density copper oleate small molecules encapsulated within a phospholipid surfactant (CuNPs) to generate a soft nanoparticle with PA contrast comparable to that from gold. Within the NIR window, the copper nanoparticles provided a 4-fold higher signal than that of blood. ανβ3-integrin targeting of CuNPs in a MatrigelTM angiogenesis mouse model demonstrated prominent (p<0.05) PA contrast enhancement of the neovasculature compared with mice given nontargeted or competitively inhibited CuNPs. Furthermore, incorporation of a Sn 2 lipase-labile fumagillin prodrug into the CuNP outer lipid membrane produced marked antiangiogenesis in the same model when targeted to the ανβ3-integrin, providing proof of concept in vivo for the first targeted PA - drug delivery agent.

Keywords: copper, nanoparticle, near-infrared imaging, photoacoustic imaging, angiogenesis imaging, anti-angiogenic therapy.

Citation styles

APA
Zhang, R., Pan, D., Cai, X., Yang, X., Senpan, A., Allen, J.S., Lanza, G.M., Wang, L.V. (2015). ανβ3-targeted Copper Nanoparticles Incorporating an Sn 2 Lipase-Labile Fumagillin Prodrug for Photoacoustic Neovascular Imaging and Treatment. Theranostics, 5(2), 124-133. https://doi.org/10.7150/thno.10014.

ACS
Zhang, R.; Pan, D.; Cai, X.; Yang, X.; Senpan, A.; Allen, J.S.; Lanza, G.M.; Wang, L.V. ανβ3-targeted Copper Nanoparticles Incorporating an Sn 2 Lipase-Labile Fumagillin Prodrug for Photoacoustic Neovascular Imaging and Treatment. Theranostics 2015, 5 (2), 124-133. DOI: 10.7150/thno.10014.

NLM
Zhang R, Pan D, Cai X, Yang X, Senpan A, Allen JS, Lanza GM, Wang LV. ανβ3-targeted Copper Nanoparticles Incorporating an Sn 2 Lipase-Labile Fumagillin Prodrug for Photoacoustic Neovascular Imaging and Treatment. Theranostics 2015; 5(2):124-133. doi:10.7150/thno.10014. https://www.thno.org/v05p0124.htm

CSE
Zhang R, Pan D, Cai X, Yang X, Senpan A, Allen JS, Lanza GM, Wang LV. 2015. ανβ3-targeted Copper Nanoparticles Incorporating an Sn 2 Lipase-Labile Fumagillin Prodrug for Photoacoustic Neovascular Imaging and Treatment. Theranostics. 5(2):124-133.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.

©2023 Ivyspring International Publisher. Terms of use