Theranostics 2012; 2(11):1104-1114. doi:10.7150/thno.4525 This issue Cite

Research Paper

Mannosylated Lipid Nano-emulsions Loaded with Lycorine-oleic Acid Ionic Complex for Tumor Cell-specific Delivery

Yangming Guo1, Xing Liu1, Xun Sun1, Qiang Zhang2, Tao Gong1,3✉, Zhirong Zhang1✉

1. Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China;
2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Peking, People's Republic of China.
3. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China.

Citation:
Guo Y, Liu X, Sun X, Zhang Q, Gong T, Zhang Z. Mannosylated Lipid Nano-emulsions Loaded with Lycorine-oleic Acid Ionic Complex for Tumor Cell-specific Delivery. Theranostics 2012; 2(11):1104-1114. doi:10.7150/thno.4525. https://www.thno.org/v02p1104.htm
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Abstract

This study was to prepare a mannosylated lycorine lipid nano-emulsion formulation (M-LYC-OA-LNEs) for the aim of achieving tumor targeting delivery of lycorine (LYC) . The low lipophilicity of LYC made it hard to be dispersed into lipid nano-emulsions (LNEs). In order to increase its lipophilicity, lycorine-oleic acid ionic complex (LYC-OA) was made. M-LYC-OA-LNEs and uncoated lycorine-oleic acid loaded lipid nano-emulsions (LYC-OA-LNEs) were prepared by solvent injection method and characterized by transmission electron microscopy (TEM), particle size, polydispersity index, zeta-potential and entrapment efficiency analysis. The in vitro cellular uptake and growth inhibition activity studies were performed on A549 cell lines. The entrapment efficiency of M-LYC-OA-LNEs was 82.7 ± 1.6 %. The cellular uptake study showed that coated LNEs were preferably taken up by A549 cells than uncoated LNEs. The effective test by MTT assay showed better growth inhibition activity of M-LYC-OA-LNEs on A549 cell lines when compared with LYC-OA-LNEs and blank LNEs. These results demonstrated that M-LYC-OA-LNEs could be a promising formulation for tumor targeting delivery of LYC with the potential of being applied in the diagnosis and treatment of cancer.

Keywords: lycorine, lipid nano-emulsion, mannosylation, tumor targeted delivery.


Citation styles

APA
Guo, Y., Liu, X., Sun, X., Zhang, Q., Gong, T., Zhang, Z. (2012). Mannosylated Lipid Nano-emulsions Loaded with Lycorine-oleic Acid Ionic Complex for Tumor Cell-specific Delivery. Theranostics, 2(11), 1104-1114. https://doi.org/10.7150/thno.4525.

ACS
Guo, Y.; Liu, X.; Sun, X.; Zhang, Q.; Gong, T.; Zhang, Z. Mannosylated Lipid Nano-emulsions Loaded with Lycorine-oleic Acid Ionic Complex for Tumor Cell-specific Delivery. Theranostics 2012, 2 (11), 1104-1114. DOI: 10.7150/thno.4525.

NLM
Guo Y, Liu X, Sun X, Zhang Q, Gong T, Zhang Z. Mannosylated Lipid Nano-emulsions Loaded with Lycorine-oleic Acid Ionic Complex for Tumor Cell-specific Delivery. Theranostics 2012; 2(11):1104-1114. doi:10.7150/thno.4525. https://www.thno.org/v02p1104.htm

CSE
Guo Y, Liu X, Sun X, Zhang Q, Gong T, Zhang Z. 2012. Mannosylated Lipid Nano-emulsions Loaded with Lycorine-oleic Acid Ionic Complex for Tumor Cell-specific Delivery. Theranostics. 2(11):1104-1114.

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