Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI

Ashwinkumar Bhirde, Ning Guo, Xiaoyuan Chen^✉

Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892

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Citation:
Bhirde A, Guo N, Chen X. Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI. Theranostics 2011; 1:274-276. doi:10.7150/thno/v01p0274. Available from https://www.thno.org/v01p0274.htm

Abstract

This commentary highlights the findings by Kessinger et al. (Theranostics 2011; 1: 263-275) that dynamic T₂*-weighted magnetic resonance imaging (MRI) of cyclic RGD peptide-encoded superparamagnetic polymeric micelle (SPPM) nanoparticles allows quantitative analysis of tumor integrin αvβ3 expression, which can exclude the effect of blood volume and extravascular signal components and thus provide less biased tumor contrast and receptor specificity of probes.

Keywords: Commentary, Superparamagnetic Nanoparticles, Integrin, Cyclic RGD Peptide, Dynamic MRI.