Theranostics 2011; 1:211-219. doi:10.7150/thno/v01p0211 This volume Cite

Review

Integrin Targeted Delivery of Gene Therapeutics

Rudy L Juliano, Xin Ming, Osamu Nakagawa, Rongzuo Xu, Hoon Yoo

Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA

Citation:
Juliano RL, Ming X, Nakagawa O, Xu R, Yoo H. Integrin Targeted Delivery of Gene Therapeutics. Theranostics 2011; 1:211-219. doi:10.7150/thno/v01p0211. https://www.thno.org/v01p0211.htm
Other styles

File import instruction

Abstract

Integrins have become key targets for molecular imaging and for selective delivery of anti-cancer agents. Here we review recent work concerning the targeted delivery of antisense and siRNA oligonucleotides via integrins. A variety of approaches have been used to link oligonucleotides to ligands capable of binding integrins with high specificity and affinity. This includes direct chemical conjugation, incorporating oligonucleotides into lipoplexes, and use of various polymeric nanocarriers including dendrimers. The ligand-oligonucleotide conjugate or complex associates selectively with the integrin, followed by internalization into endosomes and trafficking through subcellular compartments. Escape of antisense or siRNA from the endosome to the cytosol and nucleus may come about through endogenous trafficking mechanisms, or because of membrane disrupting capabilities built into the conjugate or complex. Thus a variety of useful strategies are available for using integrins to enhance the pharmacological efficacy of therapeutic oligonucleotides.

Keywords: Gene therapy, Integrin, RGD peptides, Antisense and siRNA oligonucleotides, Endosome escape.


Citation styles

APA
Juliano, R.L., Ming, X., Nakagawa, O., Xu, R., Yoo, H. (2011). Integrin Targeted Delivery of Gene Therapeutics. Theranostics, 1, 211-219. https://doi.org/10.7150/thno/v01p0211.

ACS
Juliano, R.L.; Ming, X.; Nakagawa, O.; Xu, R.; Yoo, H. Integrin Targeted Delivery of Gene Therapeutics. Theranostics 2011, 1, 211-219. DOI: 10.7150/thno/v01p0211.

NLM
Juliano RL, Ming X, Nakagawa O, Xu R, Yoo H. Integrin Targeted Delivery of Gene Therapeutics. Theranostics 2011; 1:211-219. doi:10.7150/thno/v01p0211. https://www.thno.org/v01p0211.htm

CSE
Juliano RL, Ming X, Nakagawa O, Xu R, Yoo H. 2011. Integrin Targeted Delivery of Gene Therapeutics. Theranostics. 1:211-219.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Popup Image