ISSN: 1838-7640Theranostics
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Theranostics 2011; 1:48-57. doi:10.7150/thno/v01p0048 This volume Cite
Review
PET Imaging of Integrin αVβ3 Expression
1. Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
2. Institute for Advanced Study und Center of Integrated Protein Science, Technische Universität München, Department Chemie, Garching, Germany
3. Chair for Pharmaceutical Radiochemistry, Garching, Germany
Citation:
Beer AJ, Kessler H, Wester HJ, Schwaiger M. PET Imaging of Integrin αVβ3 Expression. Theranostics 2011; 1:48-57. doi:10.7150/thno/v01p0048. https://www.thno.org/v01p0048.htm
Other stylesAbstract
PET imaging of integrin αvβ3 expression has been studied intensely by the academia and recently also by the industry. Imaging of integrin αvβ3 expression is of great potential value, as the integrin αvβ3 is a key player in tumor metastasis and angiogenesis. Therefore PET imaging of this target might be a suitable in-vivo biomarker of angiogenesis and metastatic potential of tumors. In this manuscript, the various strategies for PET imaging of the integrin αvβ3 will be summarized, including monomeric and multimeric radiolabelled RGD peptides and nanoparticles. While most experiments have been performed using preclinical tumor models, more and more clinical results on PET imaging of αvβ3 expression are available and will be discussed in detail. However, while a multitude of radiotracer strategies have been successfully evaluated for PET imaging of αvβ3, the ultimate clinical value of this new imaging biomarker still has to be evaluated in large clinical trials.
Keywords: PET, integrin αvβ3, molecular imaging, angiogenesis, metastasis
Citation styles
APA
Beer, A.J., Kessler, H., Wester, H.J., Schwaiger, M. (2011). PET Imaging of Integrin αVβ3 Expression. Theranostics, 1, 48-57. https://doi.org/10.7150/thno/v01p0048.
ACS
Beer, A.J.; Kessler, H.; Wester, H.J.; Schwaiger, M. PET Imaging of Integrin αVβ3 Expression. Theranostics 2011, 1, 48-57. DOI: 10.7150/thno/v01p0048.
NLM
Beer AJ, Kessler H, Wester HJ, Schwaiger M. PET Imaging of Integrin αVβ3 Expression. Theranostics 2011; 1:48-57. doi:10.7150/thno/v01p0048. https://www.thno.org/v01p0048.htm
CSE
Beer AJ, Kessler H, Wester HJ, Schwaiger M. 2011. PET Imaging of Integrin αVβ3 Expression. Theranostics. 1:48-57.
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