Extracellular vesicles in pathogenesis, diagnosis, or therapeutics of human diseases
Ming-Lin Liu, MD, PhD
Perelman School of Medicine
University of Pennsylvania
Philadelphia, PA, 19104, USA
On behalf of Editor-in-chief, Dr. Xiaoyuan (Shawn) Chen, and the Editorial Board of Theranostics, we would like to invite you to submit articles regarding the roles of extracellular vesicles (including exosomes, microvesicles, apoptotic bodies) in pathogenesis, diagnosis, and therapeutics of various human diseases.
Since microvesicles were first described in 1967, and exosomes were introduced in 1983, they were mainly studied in the relatively narrow area for certain biological or pathological effects. In recent years, numerous studies have demonstrated that extracellular vesicles (EVs) can serve as novel information shuttle to mediate both local autocrine and paracrine signals to the nearby cells, and the distant endocrine signals to cells far away via the transfer of signal proteins, lipids, nucleic acids (miRNAs, functional mRNAs and DNA) that they harbor. EVs have also been shown to transfer organelles from donor to recipient cells. Therefore, it has been found that EVs are involved in both physiological homeostasis of all organ systems and pathological disease processes of various human diseases. In the past few year, the rapid progress in EV research has caught increasing attention of almost all biomedical research fields. To highlight the recent advances in EV biology and the novel involvement of EVs in pathogenesis, diagnosis, and therapeutics of various human diseases, we would like to collect original research and review articles to a virtual special issue.
Manuscripts of original research addressing any novel aspects of EVs in all human diseases of either mechanistic study, or researches about diagnosis or therapeutics, are welcome to be submitted in response to this Call for Papers. Additionally, review articles on novel aspects of EV functions in all human diseases in pathogenesis, diagnosis, and therapeutics – which have not been previously reviewed in the scientific literature - will also be considered, but a pre-submission inquiry should first be made to the guest editor of this special issue.
DEADLINE for the manuscript submission of this special issue is set for July 31, 2020. All manuscripts will be reviewed promptly, thoroughly, and fairly by the recognized experts in the fields within 2-4 weeks after submission. The corresponding authors will soon be communicated after the final decision will be made.
Manuscripts for the special issue can be submitted online at https://www.thno.org/ms/submit (mark "EVs and Human Diseases Special Issue" in the "Suggested reviewers" field to identify the paper).
Detailed formatting instructions, in particular, the formatting of references, can be found in http://www.thno.org/ms/author.
All inquiries should be sent to the guest editor at the above email address.
Dr. Ming-Lin Liu is a faculty at Perelman School of Medicine, University of Pennsylvania. He received his medical education in Tianjin Medical University, China, and his PhD training in University of Helsinki, Finland. Dr. Liu started his research in extracellular vesicles from 2004. By far, he has published over 20 publications about extracellular vesicles of either original research, review articles, or book chapter in the area of cardiovascular, metabolic, and autoimmune diseases. As an expert in EV research, he has been serving as reviewers for various academic journals, ad hoc grant reviewer for grant agency, delivered invited talks in national and international meetings, as well as in his own and other research institutions.