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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.

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Research Paper
Transcriptomic profiling of murine GnRH neurons reveals developmental trajectories linked to human reproduction and infertility
Yassine Zouaghi, Daniel Alpern, Vincent Gardeux, Julie Russeil, Bart Deplancke, Federico Santoni, Nelly Pitteloud, Andrea Messina
Theranostics 2025; 15(9): 3673-3692. doi:10.7150/thno.91873
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Research Paper
Plasma extracellular vesicles from recurrent GBMs carrying LDHA to activate glioblastoma stemness by enhancing glycolysis
Xin Zhang, JunJie Li, Yiyao Huang, Anming Yang, Xiaoliu Liu, Yunhao Luo, Hao Tian, Minghui Wen, Chengzong Zhong, Bin Peng, Haitao Sun, Lei Zheng
Theranostics 2025; 15(8): 3655-3672. doi:10.7150/thno.102014
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Research Paper
Clinical value of [18F]AlF-Thretide PET/CT and early-time-point PET acquisition in the detection and staging of prostate cancer
Xin Cheng, Guozhu Hou, Mingshuai Wang, Shan Zheng, Wei Yao, Xuejuan Wang, Rong Zheng, Nianzeng Xing, Jingjing Zhang
Theranostics 2025; 15(8): 3643-3654. doi:10.7150/thno.103667
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Research Paper
Circular RNA CHACR is involved in the pathogenesis of cardiac hypertrophy
Lili Chen, Wenjing Wang, Yiheng Zhao, Shuchen Zhang, Xiang Zhou
Theranostics 2025; 15(8): 3627-3642. doi:10.7150/thno.104695
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Research Paper
Interleukin 35-producing B cells prolong the survival of GVHD mice by secreting exosomes with membrane-bound IL-35 and upregulating PD-1/LAG-3 checkpoint proteins
Jin Kyeong Choi, Evaristus C. Mbanefo, Manoj Kumar Yadav, Sahar A. Alhakeem, Vijayaraj Nagarajan, Natalia S. Nunes, Christopher G. Kanakry, Charles E. Egwuagu
Theranostics 2025; 15(8): 3610-3626. doi:10.7150/thno.105069
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Research Paper
CD19-targeted HSP90 inhibitor nanoparticle combined with TKIs reduces tumor burden and enhances T-cell immunity in murine B-cell malignancies
Mengting Qin, Juan Ren, Xiaodong Chen, Wen Zhou, Shuyuan Zhang, Weile Zhang, Mengxin Shi, Mingzhen Zhang, Huashen Liu, Yunfeng Ma, Mei Yang, Yanhong Ji
Theranostics 2025; 15(8): 3589-3609. doi:10.7150/thno.106758
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Founding Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
EIC profile

Congratulations! Professor Chen has been elected as a member of the Academia Europaea.

newTheranostics is seeking a new Editor-in-Chief. Read announcement

Rationale: Neurons producing Gonadotropin-Releasing Hormone (GnRH) are essential for human reproduction and have to migrate from nose to brain during prenatal life. Impaired GnRH neuron biology results in alterations of the reproductive axis, including delayed puberty and infertility, with considerable effects on quality of life and metabolic health. Although various genes have been implicated, the molecular causes of these conditions remain elusive, with most patients lacking a genetic diagnosis. Methods: GnRH neurons and non-GnRH cells were FACS-isolated from mouse embryo microdissections to....
Rationale: Conventional chemotherapies for B-cell malignancies are often limited by drug resistance and significant side effects due to non-specific targeting. This research aimed to improve treatment efficacy by developing nano-delivery systems that specifically target tumor cells, thereby enhancing therapeutic precision and reducing off-target toxicity. Methods: The construction, biocompatibility, and targeting capability of CD19@NP/17-DMAG were evaluated using TEM, HPLC, FTIR spectroscopy, CCK-8 assay, flow cytometry (FC), and IVIS imaging. Therapeutic efficacy was assessed through Western blotting,....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Structural Dynamics of OATP1A2 in Mediating Paclitaxel Transport Mechanism in Breast Cancer
Rohit Kumar, Garima Singh, Yusuf Akhter, Gaurav Kaithwas, Ashish Kumar Agrawal, Sanjay Singh
Nanotheranostics 2025; 9(1): 52-62.
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