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Volume 9 (10); 2019

Research Papers

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Effective targeted therapy for drug-resistant infection by ICAM-1 antibody-conjugated TPGS modified β-Ga2O3:Cr3+ nanoparticles
Xu-Qi Kang, Gao-Feng Shu, Sai-Ping Jiang, Xiao-Lin Xu, Jing Qi, Fei-Yang Jin, Di Liu, Yong-Hong Xiao, Xiao-Yang Lu, Yong-Zhong Du
Theranostics 2019; 9(10): 2739-2753. doi:10.7150/thno.33452
[Abstract] [Full text] [PDF]


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The Circadian Clock Gene Bmal1 Controls Intestinal Exporter MRP2 and Drug Disposition
Fangjun Yu, Tianpeng Zhang, Cui Zhou, Haiman Xu, Lianxia Guo, Min Chen, Baojian Wu
Theranostics 2019; 9(10): 2754-2767. doi:10.7150/thno.33395
[Abstract] [Full text] [PDF]


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A tracer-based method enables tracking of Plasmodium falciparum malaria parasites during human skin infection
Béatrice M.F. Winkel, Clarize M. de Korne, Matthias N. van Oosterom, Diego Staphorst, Anton Bunschoten, Marijke C.C. Langenberg, Séverine C. Chevalley-Maurel, Chris J. Janse, Blandine Franke-Fayard, Fijs W.B. van Leeuwen, Meta Roestenberg
Theranostics 2019; 9(10): 2768-2778. doi:10.7150/thno.33467
[Abstract] [Full text] [PDF]


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Inlaying Radiosensitizer onto the Polypeptide Shell of Drug-Loaded Ferritin for Imaging and Combinational Chemo-Radiotherapy
Qiuhong Zhang, Jingwen Chen, Jie Shen, Shixiong Chen, Kaicheng Liang, Han Wang, Hangrong Chen
Theranostics 2019; 9(10): 2779-2790. doi:10.7150/thno.33472
[Abstract] [Full text] [PDF]


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Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy
Yuan Liu, Christina S. Gong, Lisen Lin, Zijian Zhou, Yijing Liu, Zhen Yang, Zheyu Shen, Guocan Yu, Zhantong Wang, Sheng Wang, Ying Ma, Wenpei Fan, Liangcan He, Gang Niu, Yunlu Dai, Xiaoyuan Chen
Theranostics 2019; 9(10): 2791-2799. doi:10.7150/thno.34740
[Abstract] [Full text] [PDF]


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Vasoactive intestinal peptide stabilizes intestinal immune homeostasis through maintaining interleukin-10 expression in regulatory B cells
Xiong Sun, Chuanyong Guo, Fang Zhao, Jianhuan Zhu, Yilu Xu, Zhi-Qiang Liu, Gui Yang, Yuan-Yi Zhang, Xia Gu, Liang Xiao, Zhanju Liu, Ping-Chang Yang
Theranostics 2019; 9(10): 2800-2811. doi:10.7150/thno.34414
[Abstract] [Full text] [PDF]


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A Circulating Tumor Cell-RNA Assay for Assessment of Androgen Receptor Signaling Inhibitor Sensitivity in Metastatic Castration-Resistant Prostate Cancer
Yu Jen Jan, Junhee Yoon, Jie-Fu Chen, Pai-Chi Teng, Nu Yao, Shirley Cheng, Amber Lozano, Gina C.Y. Chu, Howard Chung, Yi-Tsung Lu, Pin-Jung Chen, Jasmine J. Wang, Yi-Te Lee, Minhyung Kim, Yazhen Zhu, Beatrice S. Knudsen, Felix Y. Feng, Isla P. Garraway, Allen C. Gao, Leland W. K. Chung, Michael R. Freeman, Sungyong You, Hsian-Rong Tseng, Edwin M. Posadas
Theranostics 2019; 9(10): 2812-2826. doi:10.7150/thno.34485
[Abstract] [Full text] [PDF]


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Dual-modality optical diagnosis for precise in vivo identification of tumors in neurosurgery
Mingyu Zhu, Wei Chang, Linkai Jing, Yingwei Fan, Ping Liang, Xinran Zhang, Guihuai Wang, Hongen Liao
Theranostics 2019; 9(10): 2827-2842. doi:10.7150/thno.33823
[Abstract] [Full text] [PDF]


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Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease
Jiulong Zhao, Wei Gao, Xiaojun Cai, Jiajia Xu, Duowu Zou, Zhaoshen Li, Bing Hu, Yuanyi Zheng
Theranostics 2019; 9(10): 2843-2855. doi:10.7150/thno.33727
[Abstract] [Full text] [PDF]


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QuatCy: A Heptamethine Cyanine Modification With Improved Characteristics
Sopida Thavornpradit, Syed Muhammad Usama, G. Kate Park, Jaya P. Shrestha, Shinsuke Nomura, Yoonji Baek, Hak Soo Choi, Kevin Burgess
Theranostics 2019; 9(10): 2856-2867. doi:10.7150/thno.33595
[Abstract] [Full text] [PDF]


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Imaging fibrosis in inflammatory diseases: targeting the exposed extracellular matrix
Nicolas Beziere, Kerstin Fuchs, Andreas Maurer, Gerald Reischl, Jürgen Brück, Kamran Ghoreschi, Birgit Fehrenbacher, Daniel Carvajal Berrio, Katja Schenke-Layland, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Meinrad Gawaz, Manfred Kneilling, Bernd Pichler
Theranostics 2019; 9(10): 2868-2881. doi:10.7150/thno.28892
[Abstract] [Full text] [PDF]


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The cell-penetrating FOXM1 N-terminus (M1-138) demonstrates potent inhibitory effects on cancer cells by targeting FOXM1 and FOXM1-interacting factor SMAD3
Zhenwang Zhang, Huitong Bu, Jingwei Yu, Yan Chen, Chaozhu Pei, Li Yu, Xiaoqin Huang, Guixiang Tan, Yongjun Tan
Theranostics 2019; 9(10): 2882-2896. doi:10.7150/thno.32693
[Abstract] [Full text] [PDF]


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Nano-drug System Based on Hierarchical Drug Release for Deep Localized/Systematic Cascade Tumor Therapy Stimulating Antitumor Immune Responses
Yuchu He, Cong Cong, Xiaoling Li, Ruiyan Zhu, Anshuo Li, Shuxian Zhao, Xiaowei Li, Xin Cheng, Mengxue Yang, Dawei Gao
Theranostics 2019; 9(10): 2897-2909. doi:10.7150/thno.33534
[Abstract] [Full text] [PDF]


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M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124
Yaying Song, Zongwei Li, Tingting He, Meijie Qu, Lu Jiang, Wanlu Li, Xiaojing Shi, Jiaji Pan, Linyuan Zhang, Yongting Wang, Zhijun Zhang, Yaohui Tang, Guo-Yuan Yang
Theranostics 2019; 9(10): 2910-2923. doi:10.7150/thno.30879
[Abstract] [Full text] [PDF]


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Development and characterization of a theranostic multimodal anti-PSMA targeting agent for imaging, surgical guidance, and targeted photodynamic therapy of PSMA-expressing tumors
Susanne Lütje, Sandra Heskamp, Gerben M. Franssen, Cathelijne Frielink, Annemarie Kip, Marlène Hekman, Giulio Fracasso, Marco Colombatti, Ken Herrmann, Otto C. Boerman, Martin Gotthardt, Mark Rijpkema
Theranostics 2019; 9(10): 2924-2938. doi:10.7150/thno.35274
[Abstract] [Full text] [PDF]


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Highly sensitive quantification of Alzheimer's disease biomarkers by aptamer-assisted amplification
Hei-Nga Chan, Di Xu, See-Lok Ho, Dinggeng He, Man Shing Wong, Hung-Wing Li
Theranostics 2019; 9(10): 2939-2949. doi:10.7150/thno.29232
[Abstract] [Full text] [PDF]


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CD137 promotes bone metastasis of breast cancer by enhancing the migration and osteoclast differentiation of monocytes/macrophages
Pengling Jiang, Wenjuan Gao, Tiansi Ma, Rongrong Wang, Yongjun Piao, Xiaoli Dong, Peng Wang, Xuehui Zhang, Yanhua Liu, Weijun Su, Rong Xiang, Jin Zhang, Na Li
Theranostics 2019; 9(10): 2950-2966. doi:10.7150/thno.29617
[Abstract] [Full text] [PDF]


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Lgr5-mediated p53 Repression through PDCD5 leads to doxorubicin resistance in Hepatocellular Carcinoma
Zhili Ma, Deliang Guo, Quanxiong Wang, Pengpeng Liu, Yushao Xiao, Ping Wu, Yitao Wang, Baiyang Chen, Zhisu Liu, Quanyan Liu
Theranostics 2019; 9(10): 2967-2983. doi:10.7150/thno.30562
[Abstract] [Full text] [PDF]


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A TRAIL-Delivered Lipoprotein-Bioinspired Nanovector Engineering Stem Cell-Based Platform for Inhibition of Lung Metastasis of Melanoma
Kerong Chen, Xiaoqing Cao, Min Li, Yujie Su, Huipeng Li, Mengying Xie, Ziqi Zhang, Hongbin Gao, Xiangting Xu, Yi Han, Jianping Zhou, Wei Wang
Theranostics 2019; 9(10): 2984-2998. doi:10.7150/thno.31157
[Abstract] [Full text] [PDF]


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Metabolic enzyme PDK3 forms a positive feedback loop with transcription factor HSF1 to drive chemoresistance
Jinye Xu, Qiqi Shi, Wenxia Xu, Qiyin Zhou, Rongkai Shi, Yanning Ma, Dingwei Chen, Liyuan Zhu, Lifeng Feng, Alfred Sze-Lok Cheng, Helen Morrison, Xian Wang, Hongchuan Jin
Theranostics 2019; 9(10): 2999-3013. doi:10.7150/thno.31301
[Abstract] [Full text] [PDF]