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Volume 8 (21); 2018

Editorial

Antitumoral effects of pharmacological ascorbate on gastric cancer cells: GLUT1 expression may not tell the whole story
Alessandro Corti, Eugenia Belcastro, Alfonso Pompella
Theranostics 2018; 8(21): 6035-6037. doi:10.7150/thno.29864
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Papers

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miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK1/β-Catenin Axis
Bingjie Liu, Ruikai Du, Lei Zhou, Jiahui Xu, Song Chen, Ji Chen, Xiaoli Yang, Dong-xu Liu, Zhi-ming Shao, Lixing Zhang, Zuoren Yu, Ni Xie, Jun-lin Guan, Suling Liu
Theranostics 2018; 8(21): 5801-5813. doi:10.7150/thno.29380
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A heparan sulfate-based matrix therapy reduces brain damage and enhances functional recovery following stroke
Yacine Khelif, Jérôme Toutain, Marie-Sophie Quittet, Sandrine Chantepie, Xavier Laffray, Samuel Valable, Didier Divoux, Fernando Sineriz, Emanuelle Pascolo-Rebouillat, Dulce Papy-Garcia, Denis Barritault, Omar Touzani, Myriam Bernaudin
Theranostics 2018; 8(21): 5814-5827. doi:10.7150/thno.28252
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Remote loading of liposomes with a 124I-radioiodinated compound and their in vivo evaluation by PET/CT in a murine tumor model
Gokce Engudar, Henrik Schaarup-Jensen, Frederikke P. Fliedner, Anders E. Hansen, Paul Kempen, Rasmus I. Jølck, Andreas Kjæer, Thomas L. Andresen, Mads H. Clausen, Andreas I. Jensen, Jonas R. Henriksen
Theranostics 2018; 8(21): 5828-5841. doi:10.7150/thno.26706
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages
Sean P. Arlauckas, Seth B. Garren, Chris S. Garris, Rainer H. Kohler, Juhyun Oh, Mikael J. Pittet, Ralph Weissleder
Theranostics 2018; 8(21): 5842-5854. doi:10.7150/thno.26888
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p
Mengyang Li, Wei Ding, Muhammad Akram Tariq, Wenguang Chang, Xuejuan Zhang, Wenhua Xu, Lin Hou, Yifei Wang, Jianxun Wang
Theranostics 2018; 8(21): 5855-5869. doi:10.7150/thno.27285
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Radiation-responsive scintillating nanotheranostics for reduced hypoxic radioresistance under ROS/NO-mediated tumor microenvironment regulation
Yan Dou, Yajuan Liu, Fangshi Zhao, Yanyan Guo, Xue Li, Menglin Wu, Jin Chang, Chunshui Yu
Theranostics 2018; 8(21): 5870-5889. doi:10.7150/thno.27351
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1
Panpan Zhang, Shaolei Li, Chao Lv, Jiahui Si, Ying Xiong, Lieming Ding, Yuanyuan Ma, Yue Yang
Theranostics 2018; 8(21): 5890-5902. doi:10.7150/thno.27667
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dual-Modality ImmunoPET/Fluorescence Imaging of Prostate Cancer with an Anti-PSCA Cys-Minibody
Wenting K Tsai, Kirstin A Zettlitz, Richard Tavaré, Naoko Kobayashi, Robert E Reiter, Anna M Wu
Theranostics 2018; 8(21): 5903-5914. doi:10.7150/thno.27679
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Radiomic signature of 18F fluorodeoxyglucose PET/CT for prediction of gastric cancer survival and chemotherapeutic benefits
Yuming Jiang, Qingyu Yuan, Wenbing Lv, Sujuan Xi, Weicai Huang, Zepang Sun, Hao Chen, Liying Zhao, Wei Liu, Yanfeng Hu, Lijun Lu, Jianhua Ma, Tuanjie Li, Jiang Yu, Quanshi Wang, Guoxin Li
Theranostics 2018; 8(21): 5915-5928. doi:10.7150/thno.28018
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Targeted homing of CCR2-overexpressing mesenchymal stromal cells to ischemic brain enhances post-stroke recovery partially through PRDX4-mediated blood-brain barrier preservation
Yinong Huang, Jiancheng Wang, Jianye Cai, Yuan Qiu, Haiqing Zheng, Xiaofan Lai, Xin Sui, Yi Wang, Qiying Lu, Yanan Zhang, Meng Yuan, Jin Gong, Wei Cai, Xin Liu, Yilong Shan, Zhezhi Deng, Yue Shi, Yaqing Shu, Lei Zhang, Wei Qiu, Lisheng Peng, Jie Ren, Zhengqi Lu, Andy Peng Xiang
Theranostics 2018; 8(21): 5929-5944. doi:10.7150/thno.28029
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Gut-brain axis metabolic pathway regulates antidepressant efficacy of albiflorin
Zhen-Xiong Zhao, Jie Fu, Shu-Rong Ma, Ran Peng, Jin-Bo Yu, Lin Cong, Li-Bin Pan, Zuo-Guang Zhang, Hui Tian, Chun-Tao Che, Yan Wang, Jian-Dong Jiang
Theranostics 2018; 8(21): 5945-5959. doi:10.7150/thno.28068
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Islet α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice
Xinzhi Li, Linna Jia, Xiaoyue Chen, Ying Dong, Xiaomeng Ren, Yuefan Dong, Ying Chen, Liwei Xie, Ming Liu, Chiyo Shiota, George K. Gittes, Liangyou Rui, Zheng Chen
Theranostics 2018; 8(21): 5960-5971. doi:10.7150/thno.28960
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Delivery of miR-146a to Ly6Chigh Monocytes Inhibits Pathogenic Bone Erosion in Inflammatory Arthritis
Meryem Ammari, Jessy Presumey, Clara Ponsolles, Gautier Roussignol, Christine Roubert, Virginie Escriou, Karine Toupet, Anne-Laure Mausset-Bonnefont, Maïlys Cren, Maxime Robin, Philippe Georgel, Ramzi Nehmar, Leonie Taams, Joachim Grün, Andrea Grützkau, Thomas Häupl, Yves-Marie Pers, Christian Jorgensen, Isabelle Duroux-Richard, Gabriel Courties, Florence Apparailly
Theranostics 2018; 8(21): 5972-5985. doi:10.7150/thno.29313
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Chemoresistance Transmission via Exosome-Mediated EphA2 Transfer in Pancreatic Cancer
Jia Fan, Qian Wei, Eugene J Koay, Yang Liu, Bo Ning, Paul W Bernard, Ning Zhang, Haiyong Han, Matthew H Katz, Zhen Zhao, Ye Hu
Theranostics 2018; 8(21): 5986-5994. doi:10.7150/thno.26650
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CDC20 regulates cardiac hypertrophy via targeting LC3-dependent autophagy
Yun-Peng Xie, Song Lai, Qiu-Yue Lin, Xin Xie, Jia-Wei Liao, Hong-Xia Wang, Cui Tian, Hui-Hua Li
Theranostics 2018; 8(21): 5995-6007. doi:10.7150/thno.27706
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Nanoparticles targeting extra domain B of fibronectin-specific to the atherosclerotic lesion types III, IV, and V-enhance plaque detection and cargo delivery
Mikyung Yu, Carleena A. Ortega, Kevin Si, Roberto Molinaro, Frederick J. Schoen, Renata F. C. Leitao, Xiaoding Xu, Morteza Mahmoudi, Suyeon Ahn, Jerry Liu, Phei Er Saw, In-Hyun Lee, Mirna M. B. Brayner, Azita Lotfi, Jinjun Shi, Peter Libby, Sangyong Jon, Omid C. Farokhzad
Theranostics 2018; 8(21): 6008-6024. doi:10.7150/thno.24365
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Hypoxia-triggered single molecule probe for high-contrast NIR II/PA tumor imaging and robust photothermal therapy
Xiaoqing Meng, Jiali Zhang, Zhihong Sun, Lihua Zhou, Guanjun Deng, Sanpeng Li, Wenjun Li, Ping Gong, Lintao Cai
Theranostics 2018; 8(21): 6025-6034. doi:10.7150/thno.26607
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MicroCT imaging reveals differential 3D micro-scale remodelling of the murine aorta in ageing and Marfan syndrome
Júlia López-Guimet, Lucía Peña-Pérez, Robert S. Bradley, Patricia García-Canadilla, Catherine Disney, Hua Geng, Andrew J. Bodey, Philip J. Withers, Bart Bijnens, Michael J. Sherratt, Gustavo Egea
Theranostics 2018; 8(21): 6038-6052. doi:10.7150/thno.26598
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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T-cell functionality testing is highly relevant to developing novel immuno-tracers monitoring T cells in the context of immunotherapies and revealed CD7 as an attractive target
Kristine E. Mayer, Sabine Mall, Nahid Yusufi, Dario Gosmann, Katja Steiger, Lisa Russelli, Henrique de Oliviera Bianchi, Stefan Audehm, Ricarda Wagner, Eva Bräunlein, Anja Stelzl, Florian Bassermann, Wilko Weichert, Wolfgang Weber, Markus Schwaiger, Calogero D'Alessandria, Angela M. Krackhardt
Theranostics 2018; 8(21): 6070-6087. doi:10.7150/thno.27275
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

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Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis
Jing Liu, Youichiro Wada, Mari Katsura, Hideto Tozawa, Nicholas Erwin, Carolyn M Kapron, Gang Bao, Ju Liu
Theranostics 2018; 8(21): 6053-6069. doi:10.7150/thno.30305
[Abstract] [Full text] [PDF] [PubMed] [PMC]