Indocyanine green-incorporating nanoparticles for cancer theranostics

Haolu Wang¹, Xinxing Li², Brian Wan-Chi Tse³, Haotian Yang^1,4, Camilla A. Thorling¹, Yuxin Liu⁵, Margaux Touraud⁶, Jean Batiste Chouane⁶, Xin Liu¹, Michael S. Roberts^1,7✉, Xiaowen Liang^1✉

1. Therapeutics Research Centre, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia
2. Department of General Surgery, Changzheng Hospital, The Second Military Medical University, 415S, Fengyang Road, Shanghai, 200003, China.
3. Translational Research Institute, QLD 4102, Australia
4. School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia
5. School of Environment and Biological Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China
6. Department of Pharmacy, University of Rennes 1, Ille-et-Vilaine, Rennes, 35043, France
7. School of Pharmacy and Medical Science, University of South Australia, Adelaide, SA 5001, Australia

Abstract

Indocyanine green (ICG) is a near-infrared dye that has been used in the clinic for retinal angiography, and defining cardiovascular and liver function for over 50 years. Recently, there has been an increasing interest in the incorporation of ICG into nanoparticles (NPs) for cancer theranostic applications. Various types of ICG-incorporated NPs have been developed and strategically functionalised to embrace multiple imaging and therapeutic techniques for cancer diagnosis and treatment. This review systematically summaries the biodistribution of various types of ICG-incorporated NPs for the first time, and discusses the principles, opportunities, limitations, and application of ICG-incorporated NPs for cancer theranostics. We believe that ICG-incorporated NPs would be a promising multifunctional theranostic platform in oncology and facilitate significant advancements in this research-active area.

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How to cite this article:
Wang H, Li X, Tse BWC, Yang H, Thorling CA, Liu Y, Touraud M, Chouane JB, Liu X, Roberts MS, Liang X. Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics 2018; 8(5):1227-1242. doi:10.7150/thno.22872. Available from http://www.thno.org/v08p1227.htm