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Theranostics 2018; 8(4):955-971. doi:10.7150/thno.22325 This issue Cite

Research Paper

All-in-One Theranostic Nanoplatform Based on Hollow MoSx for Photothermally-maneuvered Oxygen Self-enriched Photodynamic Therapy

Jinping Wang, Li Liu, Qing You, Yilin Song, Qi Sun, Yidan Wang, Yu Cheng, Fengping Tan, Nan Li✉

Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 300072, Tianjin, PR China.

✉ Corresponding author: School of Pharmaceutical Science and Technology, Tianjin University, 300072, Tianjin, PR China. Tel.:+86-022-27404986 E-mail address: linan19850115com

Citation:
Wang J, Liu L, You Q, Song Y, Sun Q, Wang Y, Cheng Y, Tan F, Li N. All-in-One Theranostic Nanoplatform Based on Hollow MoSx for Photothermally-maneuvered Oxygen Self-enriched Photodynamic Therapy. Theranostics 2018; 8(4):955-971. doi:10.7150/thno.22325. https://www.thno.org/v08p0955.htm
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Abstract

Graphic abstract

Photodynamic therapy (PDT) kills cancer cells by converting tumor-dissolved oxygen into reactive singlet oxygen (1O2) using a photosensitizer under laser irradiation. However, pre-existing hypoxia in tumors and oxygen consumption during PDT can result in an inadequate oxygen supply, which in turn hampers PDT efficacy. Herein, an O2 self-sufficient nanotheranostic platform based on hollow MoSx nanoparticles (HMoSx) with oxygen-saturated perfluorohexane (O2@PFH) and surface-modified human serum albumin (HSA)/chloride aluminium phthalocyanine (AlPc) (O2@PFH@HMoSx-HSA/AlPc), has been designed for the imaging and oxygen self-enriched photodynamic therapy (Oxy-PDT) of cancer.

Methods: The in vitro anti-cancer activity and intracellular 1O2 generation performance of the nanoparticles were examined using 4T1 cells. We also evaluated the multimodal imaging capabilities and anti-tumor efficiency of the prepared nanoparticles in vivo using a 4T1 tumor-bearing nude mouse model.

Results: This nanoplatform could achieve the distinct in vivo fluorescence (FL)/photoacoustic (PA)/X-ray computed tomography (CT) triple-model imaging-guided photothermally-maneuvered Oxy-PDT. Interestingly, the fluorescence and Oxy-PDT properties of O2@PFH@HMoSx-HSA/AlPc were considerably quenched; however, photothermal activation by 670 nm laser irradiation induced a significant increase in temperature, which empowered the Oxy-PDT effect of the nanoparticles. In this study, O2@PFH@HMoSx-HSA/AlPc demonstrated a great potential to image and treat tumors both in vitro and in vivo, showing complete tumor-inhibition over 16 days after treatment in the 4T1 tumor model.

Conclusion: O2@PFH@HMoSx-HSA/AlPc is promising to be used as novel multifunctional theranostic nanoagent for triple-modal imaging as well as single wavelength NIR laser triggered PTT/Oxy-PDT synergistic therapy.

Keywords: Hollow structure, Theranostic nanoagent, Triple-modal imaging, Photothermally maneuvered, Oxygen self-enriched photodynamic therapy.

Citation styles

APA
Wang, J., Liu, L., You, Q., Song, Y., Sun, Q., Wang, Y., Cheng, Y., Tan, F., Li, N. (2018). All-in-One Theranostic Nanoplatform Based on Hollow MoSx for Photothermally-maneuvered Oxygen Self-enriched Photodynamic Therapy. Theranostics, 8(4), 955-971. https://doi.org/10.7150/thno.22325.

ACS
Wang, J.; Liu, L.; You, Q.; Song, Y.; Sun, Q.; Wang, Y.; Cheng, Y.; Tan, F.; Li, N. All-in-One Theranostic Nanoplatform Based on Hollow MoSx for Photothermally-maneuvered Oxygen Self-enriched Photodynamic Therapy. Theranostics 2018, 8 (4), 955-971. DOI: 10.7150/thno.22325.

NLM
Wang J, Liu L, You Q, Song Y, Sun Q, Wang Y, Cheng Y, Tan F, Li N. All-in-One Theranostic Nanoplatform Based on Hollow MoSx for Photothermally-maneuvered Oxygen Self-enriched Photodynamic Therapy. Theranostics 2018; 8(4):955-971. doi:10.7150/thno.22325. https://www.thno.org/v08p0955.htm

CSE
Wang J, Liu L, You Q, Song Y, Sun Q, Wang Y, Cheng Y, Tan F, Li N. 2018. All-in-One Theranostic Nanoplatform Based on Hollow MoSx for Photothermally-maneuvered Oxygen Self-enriched Photodynamic Therapy. Theranostics. 8(4):955-971.

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