Active-target T1-weighted MR Imaging of Tiny Hepatic Tumor via RGD Modified Ultra-small Fe3O4 Nanoprobes

Jia, Zhengyang; Song, Lina; Zang, Fengchao; Song, Jiacheng; Zhang, Wei; Yan, Changzhi; Xie, Jun; Ma, Zhanlong; Ma, Ming; Teng, Gaojun; Gu, Ning; Zhang, Yu

doi:10.7150/thno.14280

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Theranostics 2016; 6(11):1780-1791. doi:10.7150/thno.14280 This issue Cite

Research Paper

Active-target T₁-weighted MR Imaging of Tiny Hepatic Tumor via RGD Modified Ultra-small Fe₃O₄ Nanoprobes

Zhengyang Jia^1,*, Lina Song^1,*, Fengchao Zang², Jiacheng Song³, Wei Zhang¹, Changzhi Yan¹, Jun Xie¹, Zhanlong Ma³, Ming Ma¹, Gaojun Teng², Ning Gu^1,✉, Yu Zhang^1,✉

1. State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210096, China
2. Jiangsu Key Laboratory of Molecular and Functional Imaging, Medical School, Southeast University, Nanjing 210009, China
3. Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
* These authors contributed equally to this work.

Citation:

Jia Z, Song L, Zang F, Song J, Zhang W, Yan C, Xie J, Ma Z, Ma M, Teng G, Gu N, Zhang Y. Active-target T₁-weighted MR Imaging of Tiny Hepatic Tumor via RGD Modified Ultra-small Fe₃O₄ Nanoprobes. Theranostics 2016; 6(11):1780-1791. doi:10.7150/thno.14280. https://www.thno.org/v06p1780.htm

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Abstract

Developing ultrasensitive contrast agents for the early detection of malignant tumors in liver is highly demanded. Constructing hepatic tumors specific targeting probes could provide more sensitive imaging information but still faces great challenges. Here we report a novel approach for the synthesis of ultra-small Fe₃O₄ nanoparticles conjugated with c(RGDyK) and their applications as active-target T₁-weighted magnetic resonance imaging (MRI) contrast agent (T₁-Fe₃O₄) for imaging tiny hepatic tumors in vivo. RGD-modified T₁-Fe₃O₄ nanoprobes exhibited high r₁ of 7.74 mM^-1s^-1and ultralow r₂/r₁ of 2.8 at 3 T, reflecting their excellent T₁ contrast effect at clinically relevant magnetic field. High targeting specificity together with favorable biocompatibility and strong ability to resist against non-specific uptake were evaluated through in vitro studies. Owing to the outstanding properties of tumor angiogenesis targeting with little phagocytosis in liver parenchyma, hepatic tumor as small as 2.2 mm was successfully detected via the T₁ contrast enhancement of RGD-modified T₁-Fe₃O₄. It is emphasized that this is the first report on active-target T₁ imaging of hepatic tumors, which could not only significantly improve diagnostic sensitivity, but also provide post therapeutic assessments for patients with liver cancer.

Keywords: T₁-Fe₃O₄ nanoprobes, RGD-modified, active-target, tiny hepatic tumor imaging, high diagnostic sensitivity

Citation styles

APA

Jia, Z., Song, L., Zang, F., Song, J., Zhang, W., Yan, C., Xie, J., Ma, Z., Ma, M., Teng, G., Gu, N., Zhang, Y. (2016). Active-target T₁-weighted MR Imaging of Tiny Hepatic Tumor via RGD Modified Ultra-small Fe₃O₄ Nanoprobes. Theranostics, 6(11), 1780-1791. https://doi.org/10.7150/thno.14280.

ACS

Jia, Z.; Song, L.; Zang, F.; Song, J.; Zhang, W.; Yan, C.; Xie, J.; Ma, Z.; Ma, M.; Teng, G.; Gu, N.; Zhang, Y. Active-target T₁-weighted MR Imaging of Tiny Hepatic Tumor via RGD Modified Ultra-small Fe₃O₄ Nanoprobes. Theranostics 2016, 6 (11), 1780-1791. DOI: 10.7150/thno.14280.

NLM

CSE

Jia Z, Song L, Zang F, Song J, Zhang W, Yan C, Xie J, Ma Z, Ma M, Teng G, Gu N, Zhang Y. 2016. Active-target T₁-weighted MR Imaging of Tiny Hepatic Tumor via RGD Modified Ultra-small Fe₃O₄ Nanoprobes. Theranostics. 6(11):1780-1791.

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