Theranostics 2016; 6(5):710-725. doi:10.7150/thno.14203

Review

DNA Nanotechnology for Cancer Therapy

Vinit Kumar1*, Stefano Palazzolo1,2*, Samer Bayda1,2*, Giuseppe Corona1, Giuseppe Toffoli1, Flavio Rizzolio1 ✉

1. Experimental and Clinical Pharmacology, Department of Translational Research, National Cancer Institute and Center for Molecular Biomedicine, CRO Aviano (PN), Via Franco Gallini, 2, Aviano 33081 - PN - Italy;
2. Doctoral School in Nanotechnology, University of Trieste, Italy.
* Authors equal contribution

Abstract

DNA nanotechnology is an emerging and exciting field, and represents a forefront frontier for the biomedical field. The specificity of the interactions between complementary base pairs makes DNA an incredible building material for programmable and very versatile two- and three-dimensional nanostructures called DNA origami. Here, we analyze the DNA origami and DNA-based nanostructures as a drug delivery system. Besides their physical-chemical nature, we dissect the critical factors such as stability, loading capability, release and immunocompatibility, which mainly limit in vivo applications. Special attention was dedicated to highlighting the boundaries to be overcome to bring DNA nanostructures closer to the bedside of patients.

Keywords: Nanomedicine, Nanotechnology, Cancer, Drug delivery, Doxorubicin, Self-assembly, DNA, Origami.

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How to cite this article:
Kumar V, Palazzolo S, Bayda S, Corona G, Toffoli G, Rizzolio F. DNA Nanotechnology for Cancer Therapy. Theranostics 2016; 6(5):710-725. doi:10.7150/thno.14203. Available from http://www.thno.org/v06p0710.htm