Theranostics 2016; 6(5):679-687. doi:10.7150/thno.14556 This issue Cite

Research Paper

Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer

Fangyuan Zhou1,2*, Bing Feng1*, Haijun Yu1✉, Dangge Wang1, Tingting Wang1, Jianping Liu1, Qingshuo Meng1, Siling Wang2✉, Pengcheng Zhang1, Zhiwen Zhang1, Yaping Li1✉

1. State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
2. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
* Equal contribution to this study.

Citation:
Zhou F, Feng B, Yu H, Wang D, Wang T, Liu J, Meng Q, Wang S, Zhang P, Zhang Z, Li Y. Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer. Theranostics 2016; 6(5):679-687. doi:10.7150/thno.14556. https://www.thno.org/v06p0679.htm
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Abstract

Graphic abstract

Theranostic nanomedicine has emerged as a promising modality for cancer diagnosis and treatment. In this study, we report the fabrication of fluorescence gold nanoclusters (GNC) conjugated with a cisplatin prodrug and folic acid (FA) (FA-GNC-Pt) for fluorescence imaging and targeted chemotherapy of breast cancer. The physio-chemical properties of FA-GNC-Pt nanoparticles are thoroughly characterized by fluorescence/UV-Vis spectroscopic measurement, particle size and zeta-potential examination. We find that FA-modification significantly accelerated the cellular uptake and increased the cytotoxicity of GNC-Pt nanoparticles in murine 4T1 breast cancer cells. Fluorescence imaging in vivo using 4T1 tumor bearing nude mouse model shows that FA-GNC-Pt nanoparticles selectively accumulate in the orthotopic 4T1 tumor and generate strong fluorescence signal due to the tumor targeting effect of FA. Moreover, we demonstrate that FA-GNC-Pt nanoparticles significantly inhibit the growth and lung metastasis of the orthotopically implanted 4T1 breast tumors. All these data imply a good potential of the GNC-based theranostic nanoplatform for fluorescence tumor imaging and cancer therapy.

Keywords: Theranostic Nanomedicine, Gold Nanoclusters, Fluorescence Imaging, Targeted Therapy.


Citation styles

APA
Zhou, F., Feng, B., Yu, H., Wang, D., Wang, T., Liu, J., Meng, Q., Wang, S., Zhang, P., Zhang, Z., Li, Y. (2016). Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer. Theranostics, 6(5), 679-687. https://doi.org/10.7150/thno.14556.

ACS
Zhou, F.; Feng, B.; Yu, H.; Wang, D.; Wang, T.; Liu, J.; Meng, Q.; Wang, S.; Zhang, P.; Zhang, Z.; Li, Y. Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer. Theranostics 2016, 6 (5), 679-687. DOI: 10.7150/thno.14556.

NLM
Zhou F, Feng B, Yu H, Wang D, Wang T, Liu J, Meng Q, Wang S, Zhang P, Zhang Z, Li Y. Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer. Theranostics 2016; 6(5):679-687. doi:10.7150/thno.14556. https://www.thno.org/v06p0679.htm

CSE
Zhou F, Feng B, Yu H, Wang D, Wang T, Liu J, Meng Q, Wang S, Zhang P, Zhang Z, Li Y. 2016. Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer. Theranostics. 6(5):679-687.

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