Theranostics 2015; 5(12):1428-1443. doi:10.7150/thno.13451
Phototheranostic Porphyrin Nanoparticles Enable Visualization and Targeted Treatment of Head and Neck Cancer in Clinically Relevant Models
1. Princess Margaret Cancer Centre and Techna Institute, University Health Network, Toronto, Canada.
2. Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Canada
3. Department of Pharmaceutical Sciences, University of Toronto, Toronto, Canada
4. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto,
5. Department of Medical Biophysics, University of Toronto, Toronto, Canada
6. Medical Isotopes Research Center, Peking University, Beijing, China
‡ First two authors contributed equally to this work.
Head and neck cancer is the fifth most common type of cancer worldwide and remains challenging for effective treatment due to the proximity to critical anatomical structures in the head and neck region, which increases the probability of toxicity from surgery and radiotherapy, and therefore emphasizes the importance of maximizing the targeted ablation. We have assessed the effectiveness of porphysome nanoparticles to enhance fluorescence and photoacoustic imaging of head and neck tumors in rabbit and hamster models. In addition, we evaluated the effectiveness of this agent for localized photothermal ablative therapy of head and neck tumors. We have demonstrated that porphysomes not only enabled fluorescence and photoacoustic imaging of buccal and tongue carcinomas, but also allowed for complete targeted ablation of these tumors. The supremacy of porphysome-enabled photothermal therapy over surgery to completely eradicate primary tumors and metastatic regional lymph node while sparing the adjacent critical structures' function has been demonstrated for the first time. This study represents a novel breakthrough that has the potential to revolutionize our approach to tumor diagnosis and treatment in head and neck cancer and beyond.
Keywords: Porphyrin, Nanoparticle, Fluorescence, Photoacoustic imaging, Photothermal therapy
Muhanna N, Jin CS, Huynh E, Chan H, Qiu Y, Jiang W, Cui L, Burgess L, Akens MK, Chen J, Irish JC, Zheng G. Phototheranostic Porphyrin Nanoparticles Enable Visualization and Targeted Treatment of Head and Neck Cancer in Clinically Relevant Models. Theranostics 2015; 5(12):1428-1443. doi:10.7150/thno.13451. Available from http://www.thno.org/v05p1428.htm