Theranostics 2019; 9(3):691-707. doi:10.7150/thno.31022 This issue Cite

Research Paper

Mitochondria-Responsive Drug Release along with Heat Shock Mediated by Multifunctional Glycolipid Micelles for Precise Cancer Chemo-Phototherapy

Yanan Tan2, Yun Zhu2, Lijuan Wen1, Xiqin Yang1, Xuan Liu1, Tingting Meng1, Suhuan Dai1, Yuan Ping1, Hong Yuan1, Fuqiang Hu1,2✉

1. College of Pharmaceutical Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China
2. Ocean College, Zhejiang University, 1 Zheda Road, Zhoushan 316021, China

Citation:
Tan Y, Zhu Y, Wen L, Yang X, Liu X, Meng T, Dai S, Ping Y, Yuan H, Hu F. Mitochondria-Responsive Drug Release along with Heat Shock Mediated by Multifunctional Glycolipid Micelles for Precise Cancer Chemo-Phototherapy. Theranostics 2019; 9(3):691-707. doi:10.7150/thno.31022. https://www.thno.org/v09p0691.htm
Other styles

File import instruction

Abstract

Graphic abstract

Responsive drug release in tumor mitochondria is a pre-requisite for mitochondria-targeted drug delivery systems to improve the efficacy of this promising therapeutic modality. To this end, a photothermal stimulation strategy for mitochondria-responsive drug release along with heat shock is developed to maximize the antitumor effects with minimal side effects.

Methods: This strategy relies on mitochondrial-targeted delivery of doxorubicin (DOX) through a photothermal and lipophilic agent IR-780 iodide (IR780)-modified glycolipid conjugates (CSOSA), which can synergistically triggers high-level reactive oxygen species (ROS) to kill tumor cells.

Results: Specifically, upon laser irradiation, the photothermal conversion by IR780-CSOSA can not only weaken the hydrophobic interaction between the core of micelles and DOX and trigger unexpected micelle swelling to release DOX in mitochondria for the amplification of ROS, but also induce mitochondria-specific heat shock to promote the fast evolution of ROS at the same locus to eradicate cancer cells in a more effective way. Furthermore, IR780-CSOSA micelles may independently realize the real-time diagnosis and imaging on multiple tumor models. Deep penetration into tumors by IR780-CSOSA/DOX micelles can be manipulated under laser irradiation.

Conclusion: Such multifunctional IR780-CSOSA/DOX micelles with integration of mitochondria-responsive drug release and heat shock are demonstrated to be superior to the non-mitochondria-responsive therapy. This study opens up new avenues for the future cancer diagnosis and treatment.

Keywords: mitochondria-responsive drug release, mitochondrial heat shock, glycolipid micelles, photothermal therapy, chemotherapy


Citation styles

APA
Tan, Y., Zhu, Y., Wen, L., Yang, X., Liu, X., Meng, T., Dai, S., Ping, Y., Yuan, H., Hu, F. (2019). Mitochondria-Responsive Drug Release along with Heat Shock Mediated by Multifunctional Glycolipid Micelles for Precise Cancer Chemo-Phototherapy. Theranostics, 9(3), 691-707. https://doi.org/10.7150/thno.31022.

ACS
Tan, Y.; Zhu, Y.; Wen, L.; Yang, X.; Liu, X.; Meng, T.; Dai, S.; Ping, Y.; Yuan, H.; Hu, F. Mitochondria-Responsive Drug Release along with Heat Shock Mediated by Multifunctional Glycolipid Micelles for Precise Cancer Chemo-Phototherapy. Theranostics 2019, 9 (3), 691-707. DOI: 10.7150/thno.31022.

NLM
Tan Y, Zhu Y, Wen L, Yang X, Liu X, Meng T, Dai S, Ping Y, Yuan H, Hu F. Mitochondria-Responsive Drug Release along with Heat Shock Mediated by Multifunctional Glycolipid Micelles for Precise Cancer Chemo-Phototherapy. Theranostics 2019; 9(3):691-707. doi:10.7150/thno.31022. https://www.thno.org/v09p0691.htm

CSE
Tan Y, Zhu Y, Wen L, Yang X, Liu X, Meng T, Dai S, Ping Y, Yuan H, Hu F. 2019. Mitochondria-Responsive Drug Release along with Heat Shock Mediated by Multifunctional Glycolipid Micelles for Precise Cancer Chemo-Phototherapy. Theranostics. 9(3):691-707.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image