Theranostics 2019; 9(2):466-476. doi:10.7150/thno.29130

Review

Blossoming 20: The Energetic Regulator's Birthday Unveils its Versatility in Cardiac Diseases

Jianjun Lv1,2*, Chao Deng3*, Shuai Jiang4*, Ting Ji1, Zhi Yang2, Zheng Wang5,6, Yang Yang1✉

1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an 710069, China
2. School of Basic Medicine, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China
3. Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an 710061, Shaanxi, China
4. Department of Aerospace Medicine, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China
5. Department of Cadio-Thoracic Surgery, Wuhan General Hospital of The People's Liberation Army, 627 Wuluo Road, Wuhan 430070, China
6. Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi'an 710032, China
*These authors contributed equally to this work.

Abstract

The peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) was first identified in 1998 as a PGC-1 family member that regulates adaptive thermogenesis and mitochondrial function following cold exposure in brown adipose tissue. The PGC-1 family has drawn widespread attention over the past two decades as the energetic regulator. We recently summarized a review regarding PGC-1 signaling pathway and its mechanisms in cardiac metabolism. In this review, we elaborate upon the PGC-1 signaling network and highlight the recent progress of its versatile roles in cardiac diseases, including myocardial hypertrophy, peripartum and diabetic cardiomyopathy, and heart failure. The information reviewed here may be useful in future studies, which may increase the potential of this energetic regulator as a therapeutic target.

Keywords: PGC-1, energetic regulator, cardiac diseases

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How to cite this article:
Lv J, Deng C, Jiang S, Ji T, Yang Z, Wang Z, Yang Y. Blossoming 20: The Energetic Regulator's Birthday Unveils its Versatility in Cardiac Diseases. Theranostics 2019; 9(2):466-476. doi:10.7150/thno.29130. Available from http://www.thno.org/v09p0466.htm