Theranostics 2018; 8(22):6355-6356. doi:10.7150/thno.30953


Deficiency of TLR4 ameliorates hypoperfusion-induced brain pathology

Yang Liu1,2,3✉, Klaus Fassbender1,2

1. Department of Neurology, Saarland University, 66421 Homburg, Germany;
2. German Institute for Dementia Prevention (DIDP), Saarland University, 66421 Homburg, Germany
3. Department of Clinical Laboratory, Tongji Hospital, Tongji University Medical School, 200065 Shanghai, China


Microglial inflammatory activation contributes to chronic cerebral hypoperfusion-induced brain pathology. This editorial highlights a study by Qin et al. (Theranostics 2018; 8(19):5434-5451. doi:10.7150/thno.27882) that deficiency of TLR4 attenuates cognitive dysfunction and white matter injury by reducing autophagy and pro-inflammatory activation in microglia.

Keywords: chronic cerebral hypoperfusion, microglia, inflammation, autophagy, TLR4.

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How to cite this article:
Liu Y, Fassbender K. Deficiency of TLR4 ameliorates hypoperfusion-induced brain pathology. Theranostics 2018; 8(22):6355-6356. doi:10.7150/thno.30953. Available from